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首页> 外文会议>Nestle? Nutrition Workshop >Effect of Multiple Micronutrient versus Iron-Folate Supplementation during Pregnancy on Intrauterine Growth
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Effect of Multiple Micronutrient versus Iron-Folate Supplementation during Pregnancy on Intrauterine Growth

机译：多种微量营养素对孕骨叶酸血液抑制对宫内生长的影响

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摘要

This review examines the effects of prenatal multiple micronutrient (MM) supplementation (>=5 micronutrients) on intrauterine growth. We identified publications from 16 randomized controlled trials through PubMed and EMBASE database searches. Meta-anal-yses were performed by pooling results, and sub-analyses by timing of intervention and amount of iron were also done. The primary outcome measures were birthweight, low birthweight (LBW; <2,500 g) and small for gestational age (SGA). Prenatal MM supplementation significantly reduced the incidence of LBW (risk ratio, RR: 0.86; 95% Cl: 0.81 -0.92) and SGA (RR: 0.83; 95% Cl: 0.73-0.95) compared to iron-folate supplementation; mean birthweight was significantly higher by 55 g for MM with borderline increases in gestational age. MM supplementation was associated with larger decreases in the risk of LBW and SGA in the subgroup of trials that used supplements containing 60 mg of iron, but were not statistically significantly different from those for trials that used 30 mg iron. Prenatal MM supplementation improved intrauterine growth and can be recommended instead of prenatal IFA supplements in settings where micronutrient deficiencies are common.
机译：该综述检测产前多微量营养素（mm）补充（> = 5微量营养素）对宫内生长的影响。我们通过PubMed和Embase数据库搜索确定了16个随机对照试验的出版物。通过汇集结果进行了Meta-Anal-yses，还进行了通过干预时间和铁的时间分析。主要结果措施是出生重量级，低出生体重（LBW; <2,500克）和胎龄（SGA）的小。产前MM补充显着降低了LBW的发生率（风险比，RR：0.86; 95％Cl：0.81 -0.92）和SGA（RR：0.83; 95％Cl：0.73-0.95）与铁叶酸补充剂相比;平均出生体重明显高于55克，胎儿的胎儿增加了55克。 MM补充与使用含有60mg铁的补充剂的补充剂的试验中的LBW和SGA风险的较大降低相关，但与使用30毫克铁的试验的试验没有统计学显着差异。产前MM补充改善了宫内生长，可以推荐，而不是在微量营养素缺陷常见的环境中的产前IFA补充剂。

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