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Cancer Cell Death Induction Mechanisms by Second Generation Photosensitizers

机译：第二代光敏剂癌细胞死亡诱导机制

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Photodynamic therapy (PDT) is a cancer treatment modality that induces cell death facilitated by a photosensitizer (PS) that photochemically generates reactive oxygen species upon laser irradiation. Second generation PSs such as metallosulfophthalocyanines, currently investigated as potential photochemotherapeutic agents, show great potential. The identification of novel PSs has turned the focus of PDT research on the mechanism of cell death induced. Research presented in this paper focuses on the different techniques used to elucidate the mechanism of cell death induced in oesophageal cancer cells (SNO). Results appear to indicate necrosis as the major mechanism whereby cancer cell death is induced although contribution of apoptotic factors to facilitate this process is not excluded.
机译：光动力疗法（PDT）是一种癌症治疗方式，诱导光敏剂（PS）促进的细胞死亡，所述光敏剂（PS）在激光照射时光学地产生反应性氧物质。第二代PSS如金属苯二甲酞菁，目前被研究为潜在的光化学药剂，表现出很大的潜力。新型PSS的鉴定转向了PDT研究诱导的细胞死亡机制的重点。本文提出的研究侧重于用于阐明食管癌细胞（SnO）中诱导的细胞死亡机制的不同技术。结果似乎表明坏死作为癌症细胞死亡的主要机制，尽管凋亡因子促进该过程的贡献不包括在内。

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