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首页> 外文会议>European Symposium on Computer Aided Process Engineering >A PSE approach to patient-individualized physiologically-based pharmacokinetic modeling
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A PSE approach to patient-individualized physiologically-based pharmacokinetic modeling

机译：患者个体化生理学药代动力学建模的PSE方法

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摘要

Pharmacokinetic modeling allows predicting the drug concentration reached in the blood as a consequence of a specific administration. When such models are based on mammalian anatomy and physiology it is possible to theoretically evaluate the drug concentration in every organ and tissue of the body. This is the case of the so-called physiologically based pharmacokinetic (PBPK) models. This paper proposes and validates a procedure to deploy PBPK models based on a simplified, although highly consistent with human anatomy and physiology, approach. The article aims at reducing the pharmacokinetic variations among subjects due to inter-individual variability, by applying a strategy to individualize some model parameters. The simulation results are validated respect to experimental data on remifentanil.
机译：药代动力学建模允许以特定给药的结果预测血液中达到的药物浓度。当这些模型基于哺乳动物解剖学和生理学时，可以理论上可以评估身体的每个器官和组织中的药物浓度。这是所谓的生理基础的药代动力学（PBPK）模型的情况。本文提出并验证了一种基于简化的PBPK模型的程序，尽管与人类解剖和生理学，方法高度一致。本文旨在通过适用于各种模型参数来减少因个人间可变性而导致的受试者的药代动力学变化。仿真结果验证了对雷芬丹内亚尔的实验数据。

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