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首页> 外文会议>Annual Meeting of the Japanese Association for Animal Cell Technology >Assay systems for screening food factors that have anti-proliferative and anti-invasive potential using rat ascites hepatoma cells in culture
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Assay systems for screening food factors that have anti-proliferative and anti-invasive potential using rat ascites hepatoma cells in culture

机译：用于筛选使用大鼠腹水肝癌细胞具有抗增殖和抗侵袭潜力的食物因素的测定系统

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摘要

Tumor cells are known to be derived from normal cells and this process is called carcinogenesis. Tumor cells can proliferate endlessly and often metastasize. Endless proliferation and metastasis are regarded as two biological characteristics of these cells, and tumor metastasis, in particular often threatens the life of its host. Many food factors have recently been reported to have the potential to prevent carcinogenesis and tumor growth and food factors that have the potential to suppress tumor metastasis have been also reported. Tumor cells metastasize via complicated and sequential steps (Fidler et al., 1978). First, they secede from the primary tumor and penetrate the endothelial cell layer. They are transported to distal tissues and then again penetrate the endothelial cell layer followed by the degradation of the basement membrane and extracellular matrices. The penetration across the endothelial cell layer, which is called invasion, is the most important and characteristic step in metastasis. It is thought that inhibiting the invasion can lead to the inhibition of metastasis. In this paper, we report the development of an assay system for screening food factors that have anti-proliferative and anti-invasive potential using rat ascites hepatoma cells in culture. We also report the effective components in food factors that are screened out and some insight into their mode of actions.
机译：已知肿瘤细胞衍生自正常细胞，并且该过程称为致癌作用。肿瘤细胞可以无休止地增殖并经常转移。无环的增殖和转移被认为是这些细胞的两个生物学特性，并且肿瘤转移，特别是往往威胁其宿主的生命。最近据报道，许多食物因素有可能预防致癌和肿瘤生长和患有抑制肿瘤转移的食物因素。肿瘤细胞通过复杂和顺序步骤转移（Fidler等，1978）。首先，它们从原发性肿瘤中塞住并穿透内皮细胞层。它们被运输到远端组织，然后再次穿透内皮细胞层，然后渗透地下室膜和细胞外基质的降解。被称为侵袭的内皮细胞层穿过内皮细胞层是转移中最重要和最重要的步骤。认为抑制侵袭会导致转移的抑制。在本文中，我们报告了使用大鼠培养肝癌细胞筛选具有抗增殖和抗侵袭潜力的食物因素的测定系统的开发。我们还报告了筛选的食品因素中的有效组成部分，并欣赏到他们的行为模式。

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