A Review of the Pathophysiology and Treatment of Acute Laminitis: Pathophysiologic and Therapeutic Implications of Endothelin-1

机译：急性层层炎病理生理学和治疗综述：内皮素-1的病理生理学和治疗意义

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The pathophysiology of acute laminitis remains poorly understood despite substantial scientific investigation over the last 20 yr. Evidence would suggest that ischemic and inflammatory cascades are involved. Evidence from our laboratory suggests thatendothelin-1 is involved in the digital microvascular alterations characteristic of acute laminitis. Although current therapies are varied and inconsistent in their effectiveness, newer, novel, and more effective treatments can only be developed as we gain a better understanding of the pathophysiology of this devastating disease. Based on information from our laboratory, further investigation into the potential therapeutic use of endothelin antagonists for the prevention and treatment of laminitis in horses is warranted.

机译：尽管在过去20年的大量科学调查中，急性层层炎的病理生理学仍然明显差不多。证据表明缺血和炎症瀑布涉及。来自我们实验室的证据表明，Zentothelin-1参与了急性层层炎的数字微血管改变。虽然目前的疗法在其有效性中变化并且不一致，但只能开发出更新，新颖，更有效的治疗，因为我们更好地了解这种破坏性疾病的病理生理学。根据我们的实验室的信息，有必要进一步调查潜在的治疗使用内皮蛋白拮抗剂用于预防和治疗马氏体。

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《Annual Convention of the American Association of Equine Practitioners》|2002年||共9页
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Susan C. Eades; Ashley M. S. Holm; Rustin M. Moore;
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中图分类 S821-532;
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A Review of the Pathophysiology and Treatment of Acute Laminitis: Pathophysiologic and Therapeutic Implications of Endothelin-1

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