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A SoC Bio-analysis Platform for Real-time Biological Cell Analysis-on-a-Chip

机译:用于实时生物电池分析 - 芯片的SOC生物分析平台

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Future bio-analysis devices and systems will be heavily dependent on the micro-convergence of SoC platforms 'with the disparate technologies of MEMS and microjluidics. This paper describes a bio-analysis system that will be part of a future low-power bio-analysis platform being developed jointly in the ATIPS and Bioelectrics Laboratories at the University of Calgary. The analysis technique will exploit dielectrophoresis (DEP), an electrokinetic phenomenon that has demonstrated novel and noninvasive biological cell identification, interrogation and species separation capabilities. Various electrode configurations have been previously developed and implemented, each of which can manipulate cells in a specific manner, and test microstructures have been built by fabricating the electrodes using a standard CMOS process. In this paper we generalize this concept by providing a generic electrode structure, a "lexel" (electric field element) array, which, when integrated with a processor, is capable of generating an arbitrary electric field shape, thus facilitating a programmable sequence of different cell manipulations to be performed. This paper presents a proposal for the "lexel" array, a two dimensional array of discrete, independent electrodes, and discusses it's interfacing with appropriate controlling and sensing electronic components to provide flexible cell manipulation and subsequent analysis capability as part of a System-on-Chip bio-analysis platform.
机译:未来的生物分析设备和系统将严重依赖于SOC平台的微观趋同,具有MEMS和Microb流体的不同技术。本文介绍了生物分析系统,将成为未来低功耗生物分析平台的一部分,该平台在卡尔加里大学的ATIPS和生物电解实验室中共同开发。分析技术将利用介电泳(DEP),一种电动现象,其表现出新颖的和非侵入性生物细胞鉴定,询问和物种分离能力。先前已经开发和实施了各种电极配置,每个电极配置可以以特定方式操纵细胞,并且通过使用标准CMOS工艺制造电极来构建测试微观结构。在本文中,我们通过提供通用电极结构,“Lexel”(电场元件)阵列概括了该概念,当与处理器集成时,该概念能够产生任意电场形状,从而促进不同的可编程序列要进行的细胞操纵。本文提出了“Lexel”阵列,二维离散,独立电极阵列的提议,并讨论了与适当的控制和感测电子元件的接口,以提供灵活的单元操作和随后的分析能力,作为系统的一部分 - 芯片生物分析平台。

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