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The Natural History of Vulval Intraepithelial Neoplasia (VIN)

机译:外阴上皮内瘤形成的自然历史(VIN)

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The natural history of squamous VIN continues to be the subject of considerable debate. While some consider the lesion to have a significant invasive potential, others consider that only symptomatic lesions require treatment. A number of important points need to be addressed when considering the natural history of VIN.(1) A clear distinction needs to be made between HPV related (warty/ basaloid) VIN and non HPV related differentiated VIN.(2) VIN 1 is an uncommon histological diagnosis and usually represents HPV effect or reactive change alone. Most VIN lesions present as high grade (VIN 3) histology.(3) There is no evidence that the VIN 1-3 histological spectrum represents a biological continuum.(4) Clinical observations have been of considerable assistance in defining the natural history of this lesion, e.g. spontaneous regression.(5) Discussions on the natural history of VIN have been confused by failure to clearly differentiate between the outcome of treated and untreated VIN.
机译:鳞QIN的自然历史仍然是相当大辩论的主题。虽然有些人认为病变具有重要的侵入潜力,但其他人认为只有症状病变需要治疗。在考虑VIN的自然历史时需要解决许多重要点。(1)需要在HPV相关(Warty / Basaloid)vin和非HPV相关差异的VIN之间进行明确的区别。(2)VIN 1是一个罕见的组织学诊断和通常代表单独的HPV效应或反应性变化。大多数vin病变作为高品位(Vin 3)组织学。(3)没有证据表明VIN 1-3组织学谱代表生物连续体。(4)临床观察在定义这一点的自然历史方面存在相当大的援助病变,例如自发性回归。(5)关于VIN自然历史的讨论在未能在治疗和未经治疗的vin的结果之间显然有困惑。

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