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Human Growth and Cardiovascular Disease

机译:人体生长和心血管疾病

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Low birthweight is now known to be associated with increased rates of coronary heart disease (CHD) and the related disorders, stroke, hypertension and type 2 diabetes. Associations between low birthweight and later disease have been extensively replicated in studies in different countries. They extend across the normal range of birthweight and depend on lower birthweights in relation to the duration of gestation rather than the effects of premature birth. The associations are thought to be consequences of developmental plasticity, the phenomenon by which one genotype can give rise to a range of different physiological or morphological states in response to different environmental conditions during development. Recent observations have shown that impaired growth in infancy and rapid childhood weight gain exacerbate the effects of impaired prenatal growth. CHD and the disorders related to it arise through a series of interactions between environmental influences and the pathways of growth and development that precede them.
机译:现在已知低出生重量与冠心病(CHD)和相关疾病,中风,高血压和2型糖尿病的速率增加相关。低出生体重和后期疾病之间的关联在不同国家的研究中被广泛复制。它们延伸到突出的出生体重范围,并依赖于妊娠期持续时间的较低出生体重,而不是早产的影响。据认为,缔协会是发育可塑性的后果,一种基因型可以引起一系列不同的生理或形态学状态的现象,以应对不同的环境条件。最近的观察结果表明,婴儿期和儿童快速增长的增长受损加剧了产前生长受损的影响。 CHD和与其相关的疾病通过环境影响之间的一系列相互作用以及在它们之前的生长和发展的途径之间。

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