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Impact of Fetal and Neonatal Viral (and Parasitic) Infections on Later Development and Disease Outcome

机译:胎儿和新生儿病毒(和寄生)感染对后期发育和疾病结果的影响

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It is estimated that there are 4 million neonatal deaths and. an equal number of stillbirths annually, the majority in the developing world. Neonatal deaths account for one third of deaths in children less than 5 years of age, and at least one third of neonatal deaths are related to infections. Infections also account for 80% of deaths in the post-neonatal period through 5 years of age. There are several viral and parasitic infections which produce fetal and neonatal morbidity and mortality. Neonatal infections occur during one or more perinatal periods: in utero (congenital), intrapartum (during labor and delivery), and early or late postpartum. Here the term perinatal refers to all of these stages of fetal or neonatal infections. The mechanisms of perinatal viral and parasitic infections vary depending on the specific pathogen, however, all begin with maternal infection. Following maternal infection, organisms may produce indirect pla-cental infection with or without fetal infection, direct fetal or neonatal infection, or primary maternal infection and subsequent perinatal sequelae without either placental or fetal infection. Some pathogens may produce infections by more than one mechanism. This brief report will provide an overview of the pathogenesis, general outcomes, and known pathogens associated with perinatal viral and parasitic infections.
机译:据估计,新生儿死亡人数为400万。每年在发展中国家中的大多数人每年都有平等数量的死产。新生儿死亡人员占儿童死亡人数不到5岁的死亡,至少有三分之一的新生儿死亡与感染有关。感染还占了新生儿后期死亡人数的80%,通过5岁。有几种病毒和寄生虫感染,产生胎儿和新生儿发病率和死亡率。在一个或多个围产期期间发生新生儿感染:在子宫(先天性),荨麻(在劳动和递送期间),并早期或晚期。这里的术语是胎儿的所有这些胎儿或新生儿感染的阶段。然而,围产期病毒和寄生感染的机制根据特定病原体而变化,但是所有母亲感染都开始。在母体感染之后,生物可能会产生或没有胎儿感染,直接胎儿或新生儿感染,或后母体感染以及随后的围绕胎儿或胎儿感染的间接PLA-Centent。一些病原体可以通过多种机制产生感染。本简要介绍将概述与围产期病毒和寄生感染相关的病机病机制,一般性结果和已知病原体。

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