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首页> 外文会议>World Congress on Pain >Potential Anatomical and Neurochemical Substrates of Cutaneous Pain: A Role for Meissner's Corpuscles
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Potential Anatomical and Neurochemical Substrates of Cutaneous Pain: A Role for Meissner's Corpuscles

机译：皮肤疼痛的潜在解剖学和神经化学底物：对Meissner的尸体的作用

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Most research on primary sensory neurons pertaining to nociception and pain perception has focused on smaller neurons with thin-caliber axons that are either unmyelinated C fibers or lightly myelinated A8 fibers. A wide variety of C fibers and A8 fibers collectively have preferred stimuli that cover a range of temperatures (thermoreceptors), a variety of exogenous and endogenous molecules (chemoreceptors), intense mechanical impact (high-threshold mechanoreceptors), or some polymodal combination of such stimuli (Burgess and Perl 1973; Fields 1987; Birder and Perl 1994). Extremes in such stimuli are perceived as pain. In general, C-fiber-mediated nociception has been implicated in slow, burning pain, whereas A8-fiber nociception has been implicated in sharp, pricking pain. Under a variety of pathological conditions, pain perception increases acutely or chronically due to reduced thresholds to normally noxious stimuli (hyperalgesia) or to changes that result in normally non-noxious stimuli becoming noxious (allodynia).
机译：大多数关于患有伤害和疼痛感知的主要感觉神经元的研究都集中在具有薄口径轴突的较小神经元上，这些神经元是未键定的C纤维或轻微的近髓鞘A8纤维。各种各样的C纤维和A8纤维共同刺激了一系列温度（热感受器），各种外源性和内源性分子（化学感受器），强烈的机械冲击（高阈值机制），或这些多种多种多种组合刺激（Burgess和Perl 1973; Fields 1987; Birder和Perl 1994）。这种刺激中的极端被认为是痛苦的。通常，C-纤维介导的伤害术语较慢，燃烧疼痛，而A8-纤维的伤害伴有敏锐，刺痛疼痛。在各种病理性条件下，由于通常对通常有害刺激（痛觉）的阈值或导致通常非有害刺激变得有害（Allodynia）的变化，疼痛感知急性或长期增加。

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