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Sudden Infant DeathSudden Cardiac Death?

机译:突然婴儿死亡突然死亡吗?

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The unexplained and sudden nature of death ascribed to sudden infant death syndrome (SIDS) makes an arrhythmic cause an attractive hypothesis. Over 30 years, a number of infants have been documented to have had a Long QT interval on an ECG prior to death, and a few have had documented Torsade-de-Pointes. The QT interval is normally longest at the peak time of SIDS (2-3 months). Mutations in the long QT genes have recently been identified in about one third of a series of SIDs cases; whether they are truly pathogenic is uncertain. The commonest post-mortem finding of sub-pleural petechial haemorrhage is much more suggestive of an asphyxial death, and the association with maternal smoking supports a respiratory cause. Infants who lie on then-back have a greatly reduced risk of SIDS- suggesting that heat stress may be a factor (they don't get stuck under the sheets). A minority of SIDS is due to Long-QT syndrome, perhaps heat or asphyxial stress is a trigger for ventricular tachycardia.
机译:归因于婴儿死亡综合征(SIDS)的未解释的死亡突然性质使心律失常引起有吸引力的假设。超过30年,已经记录了许多婴儿在死亡前对ECG进行了长期的QT间隔,并且少数人记录了扭曲的曲线。 Qt间隔通常在SID的峰值时间(2-3个月)最长。最近在大约三分之一的SIDS病例中鉴定了长QT基因的突变;无论它们是真正的致病性都不确定。亚胸膜瘀度出血的最常见的验尸发现更暗示窒息死亡,并且与母亲吸烟的关联支持呼吸原因。婴儿躺在后面的婴儿有大大降低了SID的风险 - 表明热应力可能是一个因素(它们不会被粘在纸下)。少数SIDS是由于LONG-QT综合征,可能热或窒息应力是心室性心动过速的触发器。

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