Human guanylate binding protein-1 (hGBP-1)characterizes and establishes a non-angiogenicendothelial cell activation phenotype ininflammatory diseases

机译：人的醋酸酯结合蛋白-1（HGBP-1）表征并建立非血管生成的细胞活化表型炎症性疾病

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Mammalian cells require oxygen and nutrients for their survival. Therefore, allcells are located within a distance below 100-20011m (the diffusion limit of oxygen)to blood vessels. Organ and tissue growth beyond this size require recruitment ofnew blood vessels by vasculogenesis or angiogenesis. Both processes are strictlyregulated by pro- and anti-angiogenic molecules. The activities of both groups offactors are in equilibrium in normal tissues, whereas a switch towards the angiogenicor anti-angiogenic side is observed in various diseases (Carmeliet, 2000; Carmelietand Jain, 2000).

机译：哺乳动物细胞需要氧气和营养物质的存活。因此，Allcells位于低于100-20011M的距离内（氧气的扩散极限）到血管。超越这种大小的器官和组织生长需要通过血管发生或血管生成来募集血管。通过Pro-和抗血管生成分子严格调节这两种过程。两组休乳器的活动在正常组织中均衡，而在各种疾病中观察到血管生成器抗血管生成侧的切换（Carmeliet，2000; Carmelietand Jain，2000）。

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《International Symposium on Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues》|2005年||共13页
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Elisabeth Naschberger; Michael Bauer; Michael Sturzl;
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中图分类 Q55-532;
关键词
Endothelial cells; Human guanylate; hGBP-1;

机译：内皮细胞;人的瓜瓜;HGBP-1;

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1. Human guanylate binding protein-1 (hGBP-1) characterizes and establishes a non-angiogenic endothelial cell activation phenotype in inflammatory diseases. [J] . Naschberger E, Bauer M, Sturzl M Advances in enzyme regulation . 2005,第0期

机译：人鸟苷酸结合蛋白-1（hGBP-1）表征并建立了炎性疾病中的非血管生成内皮细胞激活表型。
2. Homo and hetero dimerisation of the human guanylate-binding proteins hGBP-1 and hGBP-5 characterised by affinities and kinetics [J] . The FEBS journal . 2018,第11期

机译：人的醋酸盐结合蛋白HGBP-1和HGBP-5的HOMO和杂双聚合，其特征在于亲和力和动力学
3. The human guanylate-binding proteins hGBP-1 and hGBP-5 cycle between monomers and dimers only [J] . The FEBS journal . 2017,第14期

机译：人的致植物结合蛋白HGBP-1和单体和二聚体之间的HGBP-5循环
4. Human guanylate binding protein-1 (hGBP-1)characterizes and establishes a non-angiogenicendothelial cell activation phenotype ininflammatory diseases [C] . Elisabeth Naschberger, Michael Bauer, Michael Sturzl International Symposium on Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues . 2005

机译：人的醋酸酯结合蛋白-1（HGBP-1）表征并建立非血管生成的细胞活化表型炎症性疾病
5. The functions of Ras Guanyl nucleotide Releasing Protein-1 and Grb2 binding adaptor protein in immune cell signaling and activation. [D] . Liu, Yan. 2007

机译：Ras胍基核苷酸释放蛋白1和Grb2结合衔接蛋白在免疫细胞信号传导和激活中的功能。
6. Guanylate-Binding Protein-1 Expression Is Selectively Induced by Inflammatory Cytokines and Is an Activation Marker of Endothelial Cells during Inflammatory Diseases [O] . Clara Lubeseder-Martellato, Eric Guenzi, Anita Jörg, 2002

机译：鸟嘌呤结合蛋白-1表达是由炎性细胞因子选择性诱导的并且是炎性疾病期间内皮细胞的激活标记。
7. Guanylate-Binding Protein-1 Expression Is Selectively Induced by Inflammatory Cytokines and Is an Activation Marker of Endothelial Cells during Inflammatory Diseases [O] . Lubeseder-Martellato, Clara, Guenzi, Eric, Jörg, Anita, 2002

机译：鸟嘌呤结合蛋白-1表达是由炎性细胞因子选择性诱导的，并且是炎性疾病期间内皮细胞的激活标记。

Human guanylate binding protein-1 (hGBP-1)characterizes and establishes a non-angiogenicendothelial cell activation phenotype ininflammatory diseases

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