Human guanylate binding protein-1 (hGBP-1) characterizes and establishes a non-angiogenic endothelial cell activation phenotype in inflammatory diseases.

Naschberger E; Bauer M; Sturzl M

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Human guanylate binding protein-1 (hGBP-1) characterizes and establishes a non-angiogenic endothelial cell activation phenotype in inflammatory diseases.

机译：人鸟苷酸结合蛋白-1（hGBP-1）表征并建立了炎性疾病中的非血管生成内皮细胞激活表型。

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Blood vessel activation in inflammatory diseases is triggered by a myriad of different factors that partially reveal opposite activities on endothelial cells (EC). For example, inflammatory cytokines (IC) inhibit EC proliferation and induce cell adhesiveness for leukocytes. In contrast, angiogenic growth factors (AGF) activate EC proliferation and inhibit cell adhesiveness for leukocytes. In consequence, IC and AGF may induce two different activation phenotypes in EC that appear in a temporally and/or spatially coordinated manner in inflammatory tissues. Human guanylate binding protein-1 (hGBP-1) is a member of the large GTPase protein family. New results demonstrate that hGBP-1 is a specific marker of IC-activated EC that allows to differentiate the IC- and AGF-activated phenotype of EC at the single cell level, both in vitro and in vivo. In addition, hGBP-1 is the key mediator of the inhibitory effects of IC on EC proliferation and invasiveness. Both the expression pattern of hGBP-1 and its activity in EC supported the hypothesis that IC- and AGF-activation induce distinct adversely related phenotypes in EC. In future, hGBP-1 may be used as a marker to monitor the IC-induced phenotype of EC in inflammation and may also be exploited as a target to modulate EC activity in inflammatory diseases and tumor angiogenesis.

机译：炎症性疾病中的血管活化是由多种不同的因素触发的，这些因素部分地揭示了内皮细胞（EC）的相反活性。例如，炎性细胞因子（IC）抑制EC增殖并诱导白细胞的细胞粘附性。相反，血管生成生长因子（AGF）激活EC增殖并抑制白细胞的细胞粘附性。结果，IC和AGF可诱导EC中两种不同的激活表型，它们以时间和/或空间协调的方式出现在炎症组织中。人鸟苷酸结合蛋白-1（hGBP-1）是大GTPase蛋白家族的成员。新结果表明，hGBP-1是IC激活EC的特异性标记，可在体外和体内在单个细胞水平上区分EC的IC和AGF激活的表型。此外，hGBP-1是IC抑制EC增殖和侵袭性的关键介质。 hGBP-1的表达模式及其在EC中的活性均支持IC和AGF激活在EC中诱导明显不同的负相关表型的假说。将来，hGBP-1可用作监测炎症中IC诱导的EC表型的标志物，还可以用作调节炎症性疾病和肿瘤血管生成中EC活性的靶标。

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《Advances in enzyme regulation》 |2005年第0期|共13页
作者
Naschberger E; Bauer M; Sturzl M;
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正文语种 eng
中图分类基础医学;
关键词
Endothelium; Vascular; GTP-Binding Proteins; Inflammation; 内皮; 血管; GTP-结合蛋白质类; 炎症;

机译：Endothelium;Vascular;GTP-Binding Proteins;Inflammation;内皮;血管;GTP-结合蛋白质类;炎症;

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1. Human guanylate binding protein-1 (hGBP-1) characterizes and establishes a non-angiogenic endothelial cell activation phenotype in inflammatory diseases. [J] . Naschberger E, Bauer M, Sturzl M Advances in enzyme regulation . 2005,第0期

机译：人鸟苷酸结合蛋白-1（hGBP-1）表征并建立了炎性疾病中的非血管生成内皮细胞激活表型。
2. Nuclear factor-kappa B motif and interferon-alpha-stimulated response element co-operate in the activation of guanylate-binding protein-1 expression by inflammatory cytokines in endothelial cells [J] . Naschberger E, Werner T, Vicente AB, The Biochemical Journal . 2004,第Pta2期

机译：核因子-κB基序和干扰素-α刺激的响应元件协同作用于内皮细胞中炎性细胞因子激活鸟苷酸结合蛋白-1表达
3. Nuclear factor-kappaB motif and interferon-alpha-stimulated response element co-operate in the activation of guanylate-binding protein-1 expression by inflammatory cytokines in endothelial cells. [J] . Naschberger E, Werner T, Vicente AB, The Biochemical Journal . 2004,第Pta2期

机译：核因子-κB基序和干扰素-α刺激的响应元件协同作用于内皮细胞中炎性细胞因子激活鸟苷酸结合蛋白-1表达。
4. Human guanylate binding protein-1 (hGBP-1)characterizes and establishes a non-angiogenicendothelial cell activation phenotype ininflammatory diseases [C] . Elisabeth Naschberger, Michael Bauer, Michael Sturzl International Symposium on Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues . 2005

机译：人的醋酸酯结合蛋白-1（HGBP-1）表征并建立非血管生成的细胞活化表型炎症性疾病
5. The functions of Ras Guanyl nucleotide Releasing Protein-1 and Grb2 binding adaptor protein in immune cell signaling and activation. [D] . Liu, Yan. 2007

机译：Ras胍基核苷酸释放蛋白1和Grb2结合衔接蛋白在免疫细胞信号传导和激活中的功能。
6. Guanylate-Binding Protein-1 Expression Is Selectively Induced by Inflammatory Cytokines and Is an Activation Marker of Endothelial Cells during Inflammatory Diseases [O] . Clara Lubeseder-Martellato, Eric Guenzi, Anita Jörg, 2002

机译：鸟嘌呤结合蛋白-1表达是由炎性细胞因子选择性诱导的并且是炎性疾病期间内皮细胞的激活标记。
7. Guanylate-Binding Protein-1 Expression Is Selectively Induced by Inflammatory Cytokines and Is an Activation Marker of Endothelial Cells during Inflammatory Diseases [O] . Lubeseder-Martellato, Clara, Guenzi, Eric, Jörg, Anita, 2002

机译：鸟嘌呤结合蛋白-1表达是由炎性细胞因子选择性诱导的，并且是炎性疾病期间内皮细胞的激活标记。

Human guanylate binding protein-1 (hGBP-1) characterizes and establishes a non-angiogenic endothelial cell activation phenotype in inflammatory diseases.

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