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首页> 外文会议>Annual Convention of the American Association of Equine Practitioners >Preliminary Data Regarding the Subclinical Exposure Rate of Horses to West Nile Virus During the 2001 Florida Enzootic
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Preliminary Data Regarding the Subclinical Exposure Rate of Horses to West Nile Virus During the 2001 Florida Enzootic

机译：2001年佛罗里达州恩妥罗对西尼罗河病毒亚临床暴露率的初步数据

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By the time clinical West Nile virus (WNV) disease appears in a locale, widespread subclinical exposure to horses has already occurred. Therefore, it is important to vaccinate horses before the onset of the WNV season. In addition, there is little IgMresponse in horses after vaccination in the absence of field exposure. In addition, testing for WNV in suspect horses should be pursued even in vaccinated animals. The U.S. outbreak represents the largest enzootic of West Nile (WN) disease in horses inthe history of the virus worldwide. West Nile Virus (WNV), introduced to the United States in 1999, causes neurological disease in birds, horses, and humans. In 2001, 738 horses were diagnosed with WNV. In the state of Florida, WNV has caused encephalomyelitis in 492 and 497 horses in 2001 and 2002, respectively, with a 33% mortality rate.2"5 Additionally, WNV is now endemic in the United States, with 14,717 horses from 40 states affected in 2002. The IgM capture enzymelinked immunosorbent assay (ELISA)is the test of choice for recent exposure in the horse.7 IgM responses rise rapidly and then decline usually by 30 days after onset of clinical symptoms. Only anecdotal evidence exists that vaccination against WNV does not induce a significant IgM response, and therefore, does not interfere with testing. Little is known about the occurrence of subclinical disease and the degree of subclinical exposure to horses. Without this data, little inference can be drawn regarding the asymptomatic to symptomaticratio and the need for vaccination once disease has occurred in a herd. Using the IgM capture, the objective of this study was to determine the degree of subclinical exposure in horses bled during vaccination in the face of the 2001 enzootic in Florida.In addition, a second objective was to measure the post-vaccination IgM response in horses receiving a killed vaccine conditionally licensed for WNV.
机译：当时临床西尼罗病毒（WNV）疾病出现在语境中，已经发生了广泛的亚临床暴露。因此，重要的是在WNV季节发作之前疫苗。此外，在没有田间暴露的情况下疫苗接种后，马的马上很少有IgMresponse。此外，即使在接种疫苗的动物中，也应追求对可疑马匹的WNV的测试。美国爆发代表了在全世界病毒历史的马匹尼罗河（WN）疾病中最大的敌人。西尼罗河病毒（WNV）于1999年介绍给美国，导致鸟类，马和人类的神经疾病。 2001年，738匹马被诊断为WNV。在佛罗里达州的状态下，WNV分别在2001年和2002年引起了492和497匹马的脑脊髓炎，同时患有33％的死亡率.2“5，WNV现在在美国流行，影响了40个州的14,717匹马2002年。IgM捕获酶免疫吸附试验（ELISA）是对近期暴露于马的选择的测试.7 IgM反应迅速上升，然后通常在临床症状发作后30天内下降。只有轶事证据存在疫苗接种不会诱导显着的IgM反应，因此不会干扰测试。关于亚临床疾病的发生和马匹的亚临床暴露程度几乎不知道。没有这种数据，可以对有症无症状的无症状提取很少的推理一旦疾病发生了疫苗接种的需求已经发生在牛群中。使用IgM捕获，本研究的目的是确定马的亚临床暴露程度在佛罗里达州2001年Enzootic面前疫苗接种期间。此外，第二个目的是测量接受WNV有条件杀死疫苗的马匹的疫苗接种IgM反应。

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