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Cell cycle perturbation in HepG2 cell line constitutively expressing Hepatitis C virus core protein

机译：HepG2细胞系细胞周期扰动组成思考丙型肝炎病毒核心蛋白

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Hepatitis C virus (HCV) is one of the major cause of chronic liver disease with the potential for development of hepatocellular carcinoma (HCC). The core protein of HCV is known to influence a number of cellular functions. We investigated the effect of constitutively expressed HCV core protein on cell cycle progression in HepG2 cell line. The results indicated that stable expression of the core protein in un-synchronized HepG2 cells induced a reduction in cell doubling meantime and increased S phase fraction. A significant increase of c-myc stability was demonstrated in cells expressing HCV core protein. In contrast, p53 and p21 levels were unchanged. These results suggest that HCV core protein may promote cell cycle progression through increasing stability of c-myc oncoprotein, thus contributing to virus-mediated pathogenesis and hepatocarcinogenesis.

机译：丙型肝炎病毒（HCV）是慢性肝病的主要原因之一，具有肝细胞癌（HCC）的发育潜力。已知HCV的核心蛋白质影响许多细胞功能。我们研究了组成型表达HCV核心蛋白对HepG2细胞系细胞周期进展的影响。结果表明，未同步的HepG2细胞中核心蛋白的稳定表达诱导细胞倍增时间和增加的S相级分的降低。在表达HCV核心蛋白的细胞中证明了C-MYC稳定性的显着增加。相比之下，p53和p21水平不变。这些结果表明HCV核心蛋白可以通过增加C-MYC癌蛋白的稳定性来促进细胞周期进展，从而有助于病毒介导的发病机制和肝癌发生。

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《European Congress of Virology》|2004年||共6页
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A. Ruggieri M. Franco; I. Gatto; T. Harada^-; T. Miyamura; M. Rapicetta;
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中图分类病毒传染病;
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4. Cell cycle perturbation in HepG2 cell line constitutively expressing Hepatitis C virus core protein [C] . A. Ruggieri M. Franco, I. Gatto, T. Harada^-, European Congress of Virology . 2004

机译：HepG2细胞系细胞周期扰动组成思考丙型肝炎病毒核心蛋白
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机译：丙型肝炎病毒（HCV）核心蛋白的氨基酸1-20可特异性抑制HepG2细胞中HCV IRES依赖性翻译，并抑制HuH7和CV-1细胞中HCV IRES依赖性和帽依赖性翻译

Cell cycle perturbation in HepG2 cell line constitutively expressing Hepatitis C virus core protein

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