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Reconstructing Ancestral Gene Orders Using Conserved Intervals

机译:使用保守的间隔重建祖先的基因订单

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Conserved intervals were recently introduced as a measure of similarity between genomes whose genes have been shuffled during evolution by genomic rearrangements. Phylogenetic reconstruction based on such similarity measures raises many biological, formal and algorithmic questions, in particular the labelling of internal nodes with putative ancestral gene orders, and the selection of a good tree topology. In this paper, we investigate the properties of sets of permutations associated to conserved intervals as a representation of putative ancestral gene orders for a given tree topology. We define set-theoretic operations on sets of conserved intervals, together with the associated algorithms, and we apply these techniques, in a manner similar to the Fitch-Hartigan algorithm for parsimony, to a subset of chloroplast genes of 13 species.
机译:最近将节拍的间隔作为基因组在基因组重排期间在进化期间随着基因进行洗牌的基因组之间的相似性的衡量标准。基于这种相似性措施的系统发育重建提出了许多生物学,正式和算法问题,特别是具有推定祖先基因订单的内部节点的标记,以及选择良好的树拓扑。在本文中,我们研究了与保守间隔相关的排列组的性质作为给定的树拓扑的推定祖先基因订单的代表性。我们与相关算法一起定义关于保存间隔集合的设定定理操作,并以类似于关于分析的惠氏曲酮算法的方式应用这些技术,以13种的叶绿体基因的叶片基因的副本。

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