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首页> 外文会议>International Workshop on Bioinformatics and Systems Biology >Markedly Reduced Evolutionary Rates of Transcription Factors and Cytoplasmic Ribosomal RNAs and Proteins in Higher Vertebrates and Their Evolutionary Implications
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Markedly Reduced Evolutionary Rates of Transcription Factors and Cytoplasmic Ribosomal RNAs and Proteins in Higher Vertebrates and Their Evolutionary Implications

机译：显着降低了较高脊椎动物中的转录因子和细胞质核糖核酸RNA和蛋白质的进化率及其进化意义

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摘要

To reveal the relationship between organismal evolution and the molecular evolutionary rate, the temporal pattern of evolutionary rates were investigated for various genes during the course of deuterostome evolution. Deuterostome lineage leading to extant mammals was tentatively divided into two periods (the First and the Latter periods) by the time of divergence of bony fishes and mammals. For each of the First and the Latter period, evolutionary rates of 207 gene sets were calculated. In the Latter period, the evolutionary rate was significantly reduced in such informational genes as transcription factors and cytoplasmic ribosomal RNAs and proteins. In contrast, a variety of enzymes and mitochondrial ribosomal proteins evolve at nearly constant rate throughout the First and the Latter periods. The present result suggests that the increase of gene number by extensive gene duplications in the early evolution of vertebrates is responsible for the decrease of evolutionary rate.
机译：为了揭示有机体进化与分子进化率之间的关系，在氘核ostome演化过程中针对各种基因研究了进化率的时间模式。在骨鱼和哺乳动物的分歧时，导致远定哺乳动物的氘核谱系暂时分为两个时期（第一和后一段）。对于第一和后一段时间中的每一个，计算了207个基因集的进化率。在后一段时间内，这种信息基因中的进化率显着降低，作为转录因子和细胞质核糖体RNA和蛋白质。相反，各种酶和线粒体核糖体蛋白在整个第一和后一段时以几乎恒定的速率在近恒定的速率上发展。目前的结果表明，在脊椎动物早期演化中，通过广泛的基因重复增加基因数量负责进化率的降低。

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