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Prenatal Toxicity of Cyanide in Goats - a Model for Teratological Studies in Ruminants

机译:山羊氰化物的产前毒性 - 反刍动物术后术研究模型

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Several plants for human and animal feeding contain cyanogenic glycosides that release cyanide. The most important one is cassava, a very important food staple for animals in the world, especially in the tropics (Tewe, 1992). Fetal malformations havebeen linked to maternal consumption of cyanogenic plants by animals, such as pigs, horses, sheep and cattle (Prichard and Voss, 1967; Selby et al., 1971; Rodel, 1972; Seaman et al., 1981; Bradley et al., 1995), and by humans (Kumbnani et al., 1990). However, there are few studies evaluating the effects of the prenatal exposure to cyanide, cyanogenic glycosides and cyanogenic plants. In this way, studies were performed in monogastric species such as rats (Tewe et al., 1977; Olusi et al., 1979; Miller etal., 1981; Singh, 1981; Sousa, 2000), hamsters (Doherty et al., 1982; Willhite, 1982; Frakes et al., 1985), and pigs (Tewe and Maner, 1981). In all these experimental studies it was verified that exposure to cyanide itself and/or its products of biotransformation can produce fetotoxicity and/or teratogenesis. On the other hand, to our knowledge, studies of prenatal development with cyanide in ruminants were not performed until the present study.
机译:对于人类和动物饲养一些植物含有氰甙该版本氰化物。最重要的是木薯,一个很重要的主食为世界动物,尤其是在热带地区(Tewe,1992)。胎儿畸形havebeen链接到由动物氰植物,如猪,马,绵羊和牛(普瑞和沃斯,1967的母体消耗; Selby等,1971;罗德尔,1972;西曼等人,1981; Bradley等,1995),和由人类(Kumbnani等人,1990)。然而,很少有研究评估了产前接触氰化物,氰甙和氰植物的影响。通过这种方式,研究在单胃物种进行如大鼠(Tewe等,1977; Olusi等,1979;米勒等人,1981;辛格,1981;索萨,2000),仓鼠(多尔蒂等, 1982; Willhite,1982;弗雷克斯等人,1985),和猪(Tewe和马纳,1981)。在所有这些实验研究可以证实接触氰化物本身和/或其产品的生物转化可产生胎儿毒性和/或致畸。在另一方面,据我们所知,没有进行与反刍动物中氰化物胎儿发育的研究,直到目前的研究。

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