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首页> 外文期刊>Theriogenology >Prenatal toxicity of cyanide in goats - a model for teratological studies in ruminants.
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Prenatal toxicity of cyanide in goats - a model for teratological studies in ruminants.

机译：氰化物对山羊的产前毒性-反刍动物致畸研究的模型。

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Although exposure to cyanogenic plants or cyanide during pregnancy has adverse effects, no teratological study with cyanide has been conducted in goats or any other ruminant. The objective of the present study was to evaluate the effects of the maternal exposure to potassium cyanide (KCN) during pregnancy on both dams and offspring and furthermore, to develop a model for prenatal toxicological studies in ruminants. Twenty-six pregnant goats were allocated into four groups and given 0, 1.0, 2.0, or 3.0 mg KCN/kg body weight per day orally (administered via twice-daily gavage) from Day 24 of pregnancy to term. However, one control dam and another from the 3.0 mg KCN/kg per day group were sacrificed on Day 120. At birth, the kids were examined carefully for gross abnormalities. Three months after birth, the male kids and one dam from each group were sacrificed for histopathological study. Although clinical signs of poisoning were observed in dams, cyanide treatment did not alter the length of gestation or the number of live kids. Two prognata kids were born in the 3.0 mg KCN/kg group, and one dam from the same group aborted two fetuses. There were histological lesions only in the KCN-treated dam (and its fetuses) sacrificed on Day 120; these consisted of an increased number of resorption vacuoles of thyroid follicular colloid, and status spongiosis of nervous white matter. This study proposes a new animal model for teratogenic trials that could be important to evaluate the effects of chemicals throughout pregnancy in goats and potentially other ruminants.
机译：尽管在怀孕期间暴露于生氰植物或氰化物会产生不利影响，但尚未在山羊或任何其他反刍动物中进行过氰化物的致畸研究。本研究的目的是评估孕妇在怀孕期间接触氰化钾（KCN）对大坝和后代的影响，并建立反刍动物产前毒理学研究模型。从怀孕的第24天到足月，每天将26只怀孕的山羊分为四组，每天口服（通过每日两次灌胃）0、1.0、2.0或3.0 mg KCN / kg体重。但是，在第120天处死了一个对照坝和每天3.0 mg KCN / kg组的另一只。在出生时，仔细检查了孩子的总体异常情况。出生后三个月，将每组的男婴和一个大坝处死以进行组织病理学研究。尽管在大坝中观察到了中毒的临床迹象，但是氰化物治疗并没有改变妊娠期或活着孩子的数量。 3.0 mg KCN / kg组中有两个怀孕的孩子，同一组中的一个水坝流产了两个胎儿。仅在第120天处死的经过KCN处理的大坝（及其胎儿）中存在组织学病变;只有在第二天才被杀死。这些包括甲状腺滤泡胶体吸收液泡数量的增加和神经性白质的海绵状状​​态。这项研究提出了一种致畸试验的新动物模型，对于评估整个怀孕期间化学物质对山羊和其他反刍动物的影响可能很重要。

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