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The effect of methodological differences in themeasurement of Lp(a) on the interpretationof clinical data

机译：方法论差异在LP（a）测量中对临床资料解释的影响

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In the majority of clinical studies, Lp(a) levels have been determined by methods affected by apo(a) size heterogeneity. Despite the importance of this topic, no studies have been performed to evaluate the impact of method inaccuracy on the interpretation of clinical data.We have evaluated to what extent method inaccuracy affects the correct classification of subjects for being at risk or not for CAD based on their Lp(a) values Lp(a) levels were measured in samples from the Framingham study participants by out reference ELISA, by a turbidimetric method and by a commercial ELISA using an Lp(a) value of 75 nmol/1 as the clinical decision point. The number of false positive and false negative values obtained by the turbidimetric methods was almost entirely explained by the apo(a) size dependency of this assay However, the large number of false positive values obtained by the commercial ELISA method was not.To evaluate method differences in the interpretation of clinical dat,a study was performed to compare the ability of our ELISA method and a nephelometric method to predict future angina pectotis in men participating in the Physicians' Health Study. Lp(a) values determined by ELISA were associated with increased relative risk for angina while those obtained by the nephelometric method were not. The results of these two studies clearly indicate the importance of using suitable and standardized methods for risk assessment and for the interpretation of clinical outcomes.Keyword, Lp(a)
机译：在大多数临床研究中，LP（A）水平已经通过受APO（a）尺寸异质性影响的方法确定。尽管这一主题的重要性，但没有进行研究以评估方法不准确对临床数据解释的影响。我们评估了方法不准确的程度，这是基于CAD的正确分类受试者的正确分类它们的LP（a）值Lp（a）水平在来自Framingham研究参与者的样品中通过引用ELISA，通过浊度方法和商业ELISA使用75 nmol / 1作为临床决策，通过商业ELISA测量。观点。假阳性和由比浊方法获得的假阴性值的数量几乎完全由脱辅说明（a）本测定的大小依赖然而，大量由商业ELISA方法获得的假阳性值是not.To评估方法临床目的解释的差异，进行了一项研究，以比较我们的ELISA方法和尼触拉测量方法预测参与医生健康研究的男子未来的心绞痛的能力。由ELISA确定的LP（A）值与心绞痛的相对风险增加有关，而肾小序方法获得的那些则不是。这两项研究的结果清楚地表明使用适当和标准化的风险评估方法和对临床结果解释的重要性.Keyword，LP（a）

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