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Low HDL-C: lessons learned from the Turkish Heart Study

机译：低HDL-C：从土耳其心脏研究中吸取的经验教训

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Low levels of high-density lipoprotein cholesterol (HDL-C) are highly prevalent in Turks Analysis of approximately 10,000 Turkish men and women revealed the lowest HDL-C levels of any previously characterized population (~ 10-15 mg/dl lower than in western Europeans or Americans).These low HDL-C levels are primarily of genetic origin A survey of the activities of candidate enzymes and transfer proteins showed that Turks have uniquely elevated hepatic lipase mass and activity, and their hepatic lipase levels are 25-30% higher than in non-Turkish American controls As in other populations, Turkish newborns of both sexes have low total cholesterol and HDL-C levels ( - 30 mg/dl), and 8-9-year-old boys and girls have virtually identical HDL-C levels (50-60 mg/dl) similar to those in other populations.After puberty, however, HDL-C levels decrease markedly to typical adult levels, 36-37 mg/dl in males and 40-43 mg/dl in females. The mechanism for these striking reductions is unknown.Recent studies have shown that polymorphisms in the ATP-binding cassette Al protein (ABCA1) and cholesterol ester transfer protein (CETP) are associated with altered HDL-C in Turks Furthermore, a polymorphism in acyl CoA:diacylglycerol acyltiansferase (DGAT) is associated with altered body mass index (BMI), HDL-C, and blood pressure in Turks.
机译：低水平的高密度脂蛋白胆固醇（HDL-C）在土耳其人分析中高度普遍存在约10,000名土耳其男性和女性，揭示了任何以前表征的人群的最低HDL-C水平（〜10-15 mg / dl低于西部欧洲人或美国人）。这些低HDL-C水平主要是遗传来源的候选酶和转移蛋白的活动调查显示，土耳其人具有唯一升高的肝脂肪酶质量和活性，并且它们的肝脂肪酶水平较高25-30％比在其他人群中的非土耳其美国控件中，两性的土耳其新生儿总胆固醇和HDL-C水平（ - 30毫克/平方米），8-9岁的男孩和女孩几乎相同的HDL-然而，C水平（50-60 mg / dl）与其他人群类似。然而，青春期后，HDL-C水平明显减少，典型的成人水平，36-37mg / dl，男性和雌性40-43mg / dl 。这些引人注目的减少的机制是未知的。事项研究表明，ATP结合盒Al蛋白（ABCA1）和胆固醇酯转移蛋白（CETP）中的多态性进一步与土耳其人的改变的HDL-C有关，酰基COA中的多态性：二酰基甘油酰基学酶（DGAT）与土耳其人的体重指数（BMI），HDL-C和血压有关。

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