• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Conference on lasers in surgery: Advanced characterization, therapeutics, and systems >Composites Containing Albumin Protein or Cyanoacrylate Adhesives and Biodegradable Scaffolds: Part Ⅱ - In Vivo Wound Closure Study in a Rat Model
【24h】

Composites Containing Albumin Protein or Cyanoacrylate Adhesives and Biodegradable Scaffolds: Part Ⅱ - In Vivo Wound Closure Study in a Rat Model

机译：含白蛋白蛋白或氰基丙烯酸酯粘合剂的复合材料和可生物降解的支架：第Ⅱ部分 - 在大鼠模型中的体内伤口闭合研究

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Our Scaffold-Enhanced Biological Adhesive (SEBA) system was investigated as an alternative to sutures or adhesives alone for repair of wounds. Two scaffold materials were investigated: (ⅰ) a synthetic biodegradable material fabricated from poly(L-lactic-co-glycolic acid); and (ⅱ) a biologic material, small intestinal submucosa, manufactured by Cook BioTech. Two adhesive materials were also investigated: (ⅰ) a biologic adhesive composed of 50%(w/v) bovine serum albumin solder and 0.5mg/ml indocyanine green dye mixed in deionized water, and activated with an 808-nm diode laser; and (ⅱ) Ethicon's Dermabond~R, a 2-octyl-cyanoacrylate. The tensile strength and time-to-failure of skin incisions repaired in vivo in a rat model were measured at seven days postoperative. Incisions closed by protein solder alone, by Dermabond~R alone, or by suture, were also tested for comparison. The tensile strength of repairs formed using the SEBA system were 50% to 65% stronger than repairs formed by suture or either adhesive alone, with significantly less variations within each experimental group (average standard deviations of 15% for SEBA versus 38% for suture and 28% for adhesive alone). In addition, the time-to-failure curves showed a longevity not previously seen with the suture or adhesive alone techniques. The SEBA system acts to keep the dermis in tight apposition during the critical early phase of wound healing when tissue gaps are bridged by scar and granulation tissue. It has the property of being more flexible than either of the adhesives alone and may allow the apposed edges to move in conjunction with each other as a unit for a longer period of time and over a greater range of stresses than adhesives alone. This permits more rapid healing and establishment of integrity since the microgaps between the dermis edges are significantly reduced. By the time the scaffolds are sloughed from the wound site, there is greater strength and healing than that produced by adhesive alone or by wounds following suture removal. This hypothesis is supported by the data of this study, as well as, the acute tensile strength data of Part Ⅰ of this study.
机译：我们的脚手架增强的生物粘合剂（SEBA）系统被研究为单独的缝合线或粘合剂的替代方法，用于修复伤口。研究了两种支架材料：（Ⅰ）由聚（L-乳酸 - 共乙醇酸）制造的合成生物降解材料; （Ⅱ）由厨师生物技术制造的生物材料，小肠脊髓凋亡。还研究了两种粘合剂材料：（Ⅰ）由50％（W / V）牛血清白蛋白焊料组成的生物粘合剂和0.5mg / ml在去离子水中混合的吲哚菁绿色染料，并用808nm二极管激光激活; （Ⅱ）Ethicon的Dermabond〜R，一种2-辛基 - 氰基丙烯酸酯。在术后七天测量在大鼠模型中体内修复的皮肤切口的拉伸强度和失效的时间。通过单独的蛋白质焊料，单独的蛋白质焊料或通过缝合线封闭的切口进行了测试，以进行比较。使用SEBA系统形成修理的抗拉强度比通过缝合形成修理分别为50％至65％更强或任一粘合剂单独，每个实验组内显著较少变化（15％平均标准偏差SEBA与38％为缝合和单独粘合剂28％）。此外，失败的时间曲线显示了先前没有看到缝合线或粘合剂的寿命。 SEBA系统在伤口愈合的临界早期阶段，当组织间隙通过疤痕和造粒组织桥接时，SEBA系统在伤口愈合的临界愈合期间保持紧张的临界。它具有比单独的任一个更灵活的性质，并且可以允许所附边缘彼此相互移动，以便更长的时间和比单独的粘合剂更大的应力。这允许更多快速愈合和建立完整性，因为皮耳边缘之间的微吸膏显着降低。当支架从伤口部位脱落时，比缝合物除去后，粘合剂产生的强度和愈合具有更大的强度和愈合。本研究支持该假设，以及本研究第Ⅰ部分的急性拉伸强度数据支持。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号