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Relationship between body mass index and disregulation of gonadotropins in polycystic ovary syndrome

机译：多囊卵巢综合征中体重指数与促性腺激素逆转的关系

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To assess the lelationship between elevated body mass index (BMI) and basal luteinizing hormone (LH) levels and xatio of LH to follicle-stimulating hormone (FSH) in polycystic ovary syndrome (PCOS), a retrospective case-control study was performed at Human Reproduction Service, Arzobispo Loayza Hospital in Lima, Peru A total of 94 PCOS women aged between 15 and 39 years old were included All had infertility, menstrual irregularities, hyperandrogenism and polycystic ovaries detected by ultrasonography Patients were classified into two groups: case group with BMI > 25 kg/m~2 (n= 49) and control group with BMK25 kg/m~2 (n = 45). Clinical features, LH, LH/FSH ratio and insulin tolerance test were compared Chi-square test, Mann-Whitney test and Student's t-test were used for statistical analysis. Age of menarche was 12.25 +- 1.63 years in case group and 13 43 +- 1 43 years in control group (p<0.05). Ferriman's index was higher in case group: 10.75 +-5.5 vs 6.5 +-0.71 (p<0.05). In case group, 214% of patients had acanthosis nigricans compared with 2.4% in control group. LH values were 9.20 +- 4.8 and 12.44 +- 9.1 mUI/ml in groups with BMI>25 and BMK25, respectively (p<0.05) The LH/FSH ratio did not differ between both groups with values of 1.2 +- 0.7 and 1,40 +- 1.0, respectively. Insulin sensitivity index was reduced and there were no differences between case and control groups: 0.39 +-0.19 vs.. 0.38 +- 0.06, respectively. We conclude that LH levels were lower in PCOS patients with a BMI > 25 and there is evidence of lower insulin sensitivity both in overweight and lean PCOS women.
机译：评估升高的体重指数（BMI）和基底叶氏素（LH）水平和LH的基础叶氏素（LH）水平（FSH）中的卵黄素（FSH）（PCOS），在人类中进行了回顾性案例对照研究。秘鲁的亚拉比斯波余地医院Arzobispo Loayza医院共有15至39岁的PCOS女性，包括不孕症，经过超声检查患者检测到的月经不规则性，高衰弱和多囊卵巢，分为两组：案例组与BMI > 25kg / m〜2（n = 49）和BMK25 kg / m〜2的对照组（n = 45）。将临床特征，LH，LH / FSH比率和胰岛素耐受性进行比较Chi-Square试验，Mann-Whitney试验和学生的T检验用于统计分析。液体年龄为12.25 + - 1.63年，案例组，对照组13 43 + 13岁（P <0.05）。案例组的菲里曼的指数较高：10.75 + -5.5 Vs 6.5 + -0.71（P <0.05）。在病例组中，214％的患者患有髋臼菌病尼霉菌与对照组的2.4％相比。 LH值分别为3.20±4.8和12.44±9.1毫米/ mL，分别为BMI> 25和BMK25（P <0.05），SH / FSH比率在两个群体之间没有差异为1.2±0.7和1分别为40 + - 1.0。胰岛素敏感性指数降低，病例和对照组之间没有差异：0.39±0.19 Vs .. 0.38 + - 0.06。我们得出结论，PCOS患者的LH水平低于BMI> 25，并且存在超重和精益PCOS女性胰岛素敏感性较低的证据。

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