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PRELIMINARY RESULTS OF A PHARMACOKINETIC STUDY OF HUMAN GROWTH HORMONE IN OCTODEX? MICROSPHERES IN HEALTHY VOLUNTEERS

机译：八大末端人体生长激素药代动力学研究的初步结果？健康志愿者的微球

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We have developed biodegradable hydrogel microspheres (OctoDEX?) based on crosslinked dextran (Dex-HEMA), loaded with recombinant human growth hormone (hGH). A clinical proof-of-concept study in healthy, male elderly volunteers showed an anticipated serum hGH profile, based on known human pharmacokinetics of hGH, and the in vitro release characteristics of the microsphere formulation. The biomarker IGF-1 showed hGH bioactivity after release from microspheres in vivo. Preliminary data are presented.

机译：我们开发了基于交联的葡聚糖（DEX-HEMA）的可生物降解的水凝胶微球（Octodexα），其加载重组人生长激素（HGH）。健康的临床概念验证研究，男性老年志愿者展示了预期的血清HGH型，基于HGH的已知人类药代动力学以及微球体制剂的体外释放特性。生物标志物IGF-1在体内释放微球后显示HGH生物活性。提出了初步数据。

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《Controlled Release Society annual meeting》|2004年||共2页
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中图分类生物工程学（生物技术）;
关键词
Microspheres; pharmacokinetics; clinical; drug delivery systems;

机译：微球;药代动力学;临床;药物递送系统;

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1. Pharmacokinetic study of Growth Hormone-Releasing Peptide 6 (GHRP-6) in nine male healthy volunteers [J] . CabralesA., GilJ., FernándezE., European journal of pharmaceutical sciences . 2013,第1a2期

机译：生长激素释放肽6（GHRP-6）在9名男性健康志愿者中的药代动力学研究
2. Determination of benzonatate and its metabolite in human plasma by HPLC-MS/MS: A preliminary pharmacokinetic study in healthy Chinese volunteers after oral administration of benzonatate soft capsule [J] . Man Jiayu, Jiao Feifei, Wang Yiya, Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis . 2019,第期

机译：HPLC-MS / MS测定人血浆中的苯甲酸盐及其代谢物：口服肝脏软胶囊中健康中国志愿者的初步药代动力学研究
3. Safety, tolerability, pharmacokinetics, and efficacy of AMG 403, a human anti-nerve growth factor monoclonal antibody, in two phase I studies with healthy volunteers and knee osteoarthritis subjects [J] . Jason M. Gow, Wayne H. Tsuji, Gary J. Williams, Arthritis research & therapy. . 2015,第Mara期

机译：AMG 403的安全性，耐受性，药代动力学和疗效，一种人抗神经生长因子单克隆抗体，两阶段I期，其与健康志愿者和膝关节骨关节炎受试者进行研究
4. PRELIMINARY RESULTS OF A PHARMACOKINETIC STUDY OF HUMAN GROWTH HORMONE IN OCTODEX? MICROSPHERES IN HEALTHY VOLUNTEERS [C] . Controlled Release Society annual meeting . 2004

机译：八大末端人体生长激素药代动力学研究的初步结果？健康志愿者的微球
5. Pharmacokinetics of artesunate in healthy volunteers. [D] . Naik, Himanshu. 2007

机译：青蒿琥酯在健康志愿者中的药代动力学。
6. Safety tolerability pharmacokinetics and efficacy of AMG 403 a human anti-nerve growth factor monoclonal antibody in two phase I studies with healthy volunteers and knee osteoarthritis subjects [O] . Jason M. Gow, Wayne H. Tsuji, Gary J. Williams, 2015

机译：在两项针对健康志愿者和膝骨关节炎受试者的I期研究中人抗神经生长因子单克隆抗体AMG 403的安全性耐受性药代动力学和功效
7. Safety, tolerability, pharmacokinetics, and efficacy of AMG 403, a human anti-nerve growth factor monoclonal antibody, in two phase I studies with healthy volunteers and knee osteoarthritis subjects [O] . 2015

机译：在一项针对健康志愿者和膝盖骨关节炎受试者的两项I期研究中，人抗神经生长因子单克隆抗体AMG 403的安全性，耐受性，药代动力学和功效

PRELIMINARY RESULTS OF A PHARMACOKINETIC STUDY OF HUMAN GROWTH HORMONE IN OCTODEX? MICROSPHERES IN HEALTHY VOLUNTEERS

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