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首页> 外文会议>IUPAP International Conference on Women in Physics >Training an All-Female Undergraduate Team to Design a Microscope Incubator and Microfluidic Devices for Single-Cell Studies
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Training an All-Female Undergraduate Team to Design a Microscope Incubator and Microfluidic Devices for Single-Cell Studies

机译：培养一支全女本科团队，为单细胞研究设计显微镜孵化器和微流体装置

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Individual cells exhibit a range of responses when exposed to the same external stimulus. Currently, many research techniques allow scientists to study ensemble averages of cellular responses, but few techniques exist that allow scientists to study the response of individual cells non-invasively. In our research, we are attempting to collect histograms of viral production versus time from individual cells transfected with the HIV-1 structural protein Gag. Our technique combines custom-built microfluidic devices with fluorescent imaging. Characterization of differences across a cell population will provide insight into specific cellular mechanisms involved in virus production. Our research team works at St. Catherine University (St. Kate's), a university with a small women's liberal arts college at its core. The mission of our institution requires that the goals of our research team are to not only conduct scientific research, but also to prepare traditionally underrepresented women for graduate work and employment in STEM fields. In the past five years, 10 women with diverse backgrounds have contributed significantly to our group, with training in nanofabrication, computer programming, machine shop work, biochemistry, and other skills as needed. The projects and techniques that our group focuses on are specifically designed to provide an environment that encourages women to consider careers in nanotechnology and engineering. Even with limited funding and program size, our research program is achieving our goals to develop new biophysical techniques to study viral production and increase the number of women interested in nanotechnology and physics.
机译：当暴露于相同的外部刺激时，个体细胞表现出一系列响应。目前，许多研究技巧允许科学家研究细胞反应的集合平均值，但存在很少的技术，使科学家允许科学家们研究单个细胞的响应是非侵入性的。在我们的研究中，我们试图从用HIV-1结构蛋白堵塞转染的个体细胞来收集病毒生产与时间的直方图。我们的技术将定制的微流体装置与荧光成像结合起来。细胞群体的差异表征将提供对病毒生产中的特定细胞机制的洞察。我们的研究团队在圣凯瑟琳大学（圣凯特），一所大学，核心小型女子自由艺术学院。我们的机构的使命要求我们的研究团队的目标不仅要进行科学研究，而且还要准备传统的代表性妇女，为斯蒂芬的研究生工作和就业。在过去的五年中，有10个不同的背景妇女对我们的集团贡献了很大贡献，在纳米制造，计算机编程，机器店工作，生物化学和其他需要的培训。我们的团队专注的项目和技术专门设计用于提供鼓励妇女考虑纳米技术和工程职业的环境。即使有限的资金和计划规模，我们的研究计划也在实现我们的目标，以开发新的生物物理技术，以研究病毒生产，并增加对纳米技术和物理感兴趣的妇女人数。

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