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首页> 外文会议>International Symposium on Multifunctional and Functionally Graded Materials(FGM2004) >Development of Multifunctional Materials (MFM): Bioabsorbable Drug-Releasing Hard Tissue Fixation Screws
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Development of Multifunctional Materials (MFM): Bioabsorbable Drug-Releasing Hard Tissue Fixation Screws

机译：多功能材料的开发（MFM）：生物可吸收药物释放硬组织固定螺钉

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To develop a successful bone fixation device that can also release therapeutic agents such as antibiotics one has to consider mechanical, drug release, and biocompatibility properties. We have used bioabsorbable polymers (PLGA 80/20 or PLDLA 70/30) as the matrix and ciprofloxacin (CF) as antibiotic to develop such an implant. Initial shear strengths of the studied ciprofloxacin-releasing screws were 152 MPa (P/L/DL)LA) and 172 MPa (PLGA). Studied screws retained their mechanical properties for least 12 weeks (P(L/DL)LA) and 9 weeks (PLGA) in vitro at the level that ensures their fixation properties. Pull-out tests indicated that the early version of screws have lower values as compared to controls. CF was found to be released after 44 weeks (P/L/DL)LA) and 23 weeks (PLGA) in vitro. It remained in the range of 0.06 - 8.7 μg/ml/day (for P(L/DL)LA) and 0.6 -11.6 μg/ml/day (for PLGA) after the jump start. Release CF was demonstrated to significantly inhibit S. epidermides growth, attachment and biofilm formation different than controls. Histology showed no difference from plain polymer screws, except for increased giant cells at the implantation site. Accordingly, SR-P(L/DL)LA and SR-PLGA MF implants were considered appropriate to proceed to pilot clinical application.
机译：为了开发一种成功的骨固定装置，还可以释放治疗剂，例如抗生素，必须考虑机械，药物释放和生物相容性。我们用生物可吸收的聚合物（PLGA 80/20或PLDLA 70/30）作为基质和环丙沙星（CF）作为抗生素以产生这种植入物。所研究的环丙沙星释放螺钉的初始剪切强度为152MPa（P / L / DL）LA和172MPa（PLGA）。研究在确保其固定性能的水平下，所研究的螺钉将其在体外保持至少12周（P（L / DL）La）和9周（PLGA）。拉出测试表明，与控制相比，早期版本的螺钉具有较低的值。发现CF在体外44周（p / l / dl）1a）和23周（PLGA）后被释放。跳跃开始后，它仍保持在0.06-8.7μg/ ml /天（对于p（l / dl）la）和0.6-11.6μg/ ml /天（用于PLGA）。释放CF被证明是显着抑制S. ePiDermides生长，附着品和生物膜形成不同的对照。组织学与普通聚合物螺钉没有差异，除了植入部位的巨细胞增加。因此，认为SR-P（L / DL）LA和SR-PLGA MF植入物被认为是适当的，以进行导频临床应用。

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