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首页> 外文期刊>Journal of Materials Science. Materials in Medicine >Innovation in multifunctional bioabsorbable osteoconductive drug-releasing hard tissue fixation devices
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Innovation in multifunctional bioabsorbable osteoconductive drug-releasing hard tissue fixation devices

机译：多功能生物吸收性骨传导药物释放硬组织固定装置的创新

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We review in this paper the work performed by our group to develop multifunctional bioabsorbable ciprofloxacin releasing bone implants. Poly lactide-co-glycolide (PLGA 80/20 and polylactide (P(L/DL)LA 70/30) were used. Ciprofloxacin (CF) and bioactive glass (BaG) 13-93 were added. The mixture was then extruded and self-reinforced. CF release, mechanical strength, and the effect on S. epidermidis attachment and biofilm formation were evaluated. In rabbits, tissue reactions were assessed. Pull out strength was evaluated in cadaver bones. CF was released over 44 weeks (P(L/DL)LA) and 23-26 weeks (PLGA). Initial shear strength of the CF screws was 152 MPa (P(L/DL)LA) and 172 MPa (PLGA). Strength was retained for 12 weeks (P(L/DL)LA) and 9 weeks (PLGA). Histolog-ically, CF releasing implants did not show much difference from control plain PLGA screws except for increased giant cells. CF mini screws had lower pullout strength than the controls, but CF tacks had better values than controls. BaG led to a drop in pullout strength properties. Bacterial growth, attachment and biofilm formation on CF implants was sig- nificantly reduced when compared to controls. Accordingly, bioabsorbable multifunctional implants with appropriate CF release, mechanical, and biocompatibility properties are possible to develop and are considered appropriate to apply clinically.
机译：我们在本文中回顾了我们小组为开发多功能可生物吸收的环丙沙星释放骨植入物所做的工作。使用聚丙交酯-乙交酯（PLGA 80/20和聚丙交酯（P（L / DL）LA 70/30），加入环丙沙星（CF）和生物活性玻璃（BaG）13-93，然后将混合物挤出并评估CF的释放，机械强度以及对表皮葡萄球菌附着和生物膜形成的影响。评估兔的组织反应。评估尸体骨骼的拉出强度.CF释放超过44周（P（ L / DL）LA）和23-26周（PLGA）。CF螺钉的初始剪切强度分别为152 MPa（P（L / DL）LA）和172 MPa（PLGA）。强度保持12周（P（ L / DL）LA）和9周（PLGA）。从组织学上讲，CF释放的植入物与对照组的普通PLGA螺钉相比没有太大差异，除了增加了巨大的细胞外，CF微型螺钉的拔出强度比对照组低，但CF钉BaG比对照具有更好的价值； BaG导致抗拉强度特性下降； CF植入物上的细菌生长，附着和生物膜形成显着与对照组比较时产生。因此，具有适当的CF释放，机械和生物相容性的可生物吸收的多功能植入物是可能开发的，并被认为适合临床应用。

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