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首页> 外文会议>Falk Symposium >Serum interleukin-1(beta) decreased faster than interleukin 1 receptor antagonist during recovery in children with active ulcerative colitis
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Serum interleukin-1(beta) decreased faster than interleukin 1 receptor antagonist during recovery in children with active ulcerative colitis

机译：血清白细胞介素-1（β）在有活性溃疡性结肠炎的儿童的恢复期间比白细胞介素1受体拮抗剂更快地降低

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Introduction: It is known that there are increased concentrations of interleukin 1(beta) (IL-1(beta)) and interleukin 1 receptor antagonist (IL-lra) in serum, stools and colonic mucosal specimens in ulcerative colitis (UC) children. The aim of the present study was to estimate IL-l(beta) and IL-lra in serum during recovery, and evaluate their correlations with clinical, endoscopic and histopathological UC activity.Methods: Twenty children with active UC, 14 children with non-specific colitis (NC, inflammatory control group) and 14 healthy children (normal control group) were included in the study. The interleukin concentrations were measured in the serum of UC children during admission to the hospital and after 4 and 12 weeks of treatment, using commercial quantitative ELISA immunoassays (R&D Systems, MN, USA). The Truelove-Witts clinical activity index was calculated. The endoscopic and histopathological findings were graded by Roths endoscopic scale and standard histopathological scale.
机译：介绍：已知在血清，粪便和结肠粘膜标本（UC）儿童中，在血清，粪便和结肠粘膜标本中含有增加的白细胞介素1（β））和白细胞介素1受体拮抗剂（IL-LRRA）的浓度增加。本研究的目的是在恢复过程中估算血清中的IL-L（β）和IL-LRA，并评估其与临床，内窥镜和组织病理学UC活性的相关性。方法：20名患有活跃UC的儿童，14名儿童非研究中包括特异性结肠炎（NC，炎症对照组）和14例健康儿童（正常对照组）。在进入医院的UC儿童血清中测量白细胞介素浓度，并使用商业定量ELISA免疫测定（R＆D Systems，Mn，USA）在治疗4和12周后测量。计算TRUELOVE-WITTS临床活动指数。内窥镜和组织病理学发现由罗斯内窥镜尺度和标准组织病理学规模进行分级。

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