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Alcoholic hepatitis

机译：酒精性肝炎

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Chronic consumption of alcohol results in a spectrum of liver abnormalities, ranging from simple fatty liver to steatohepatitis, cirrhosis and hepatocellular carcinoma. Fatty liver is often unnoticed and reverses within a few weeks of sobriety. Only a minority of consistent, heavy drinkers with hepatic steatosis ever develop clinically relevant liver disease. The latter observation suggests the importance of other host or environmental factors in determining the evolution of alcohol-related liver disease. Risk factors for serious liver damage in habitual alcohol drinkers include certain polymorphisms in alcohol-metabolizing enzymes, obesity, exposure to other hepatotoxins (e.g. acetaminophen), and infection with hepatitis C. A high prevalence of hepatitis C virus infection (up to 65%) has been recognized in alcoholics. These patients tend to have more severe disease, decreased survival and an increased risk of hepatocellular carcinoma. In many patients a specific co-morbidity factor is never identified.
机译：慢性消耗酒精会导致肝脏异常的光谱，从简单的脂肪肝脏到脱脂性肝炎，肝硬化和肝细胞癌。脂肪肝通常被忽视并在令人讨厌的几周内逆转。只有少数一致，患有肝脏脂肪变性的少数饮酒者在临床上发挥相关的肝病。后一种观察表明其他宿主或环境因素在确定酒精相关肝病的演变方面的重要性。习惯性酒精饮酒者严重肝脏损伤的风险因素包括某些多态性的酒精代谢酶，肥胖，暴露于其他肝素（例如乙酰氨基酚），以及用丙型肝炎感染的感染。丙型肝炎病毒感染的高度普及率（高达65％）已经在酗酒者中得到了认可。这些患者往往具有更严重的疾病，减少存活率和肝细胞癌的风险增加。在许多患者中，从未识别出特定的共发病率因子。

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