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Chemopreventive role of mesalazine in inflammatory bowel disease-associated colorectal cancer: the role of DNA methylation

机译：中甲嗪在炎症肠病相关结直肠癌中的化学预防作用：DNA甲基化的作用

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Inflammatory bowel disease (IBD) is a collective term for a group of idiopathic intestinal conditions typified by ulcerative colitis (UC) and Crohn's disease (CD). IBD is a chronic relapsing disorder associated with uncontrolled inflammation of the colonic mucosa. IBD affects more than 1 million individuals in the United States, and about 35 000 new cases are reported each year1. Patients with both long-standing extensive UC and CD are at an increased risk of developing colorectal cancer (CRC). Most of our current knowledge concerning risk factors for CRC is based on information obtained from patients with UC. However, the majority of studies examining the incidence of colon cancer in Crohn's colitis have also demonstrated an increased risk that was either similar or slightly lower compared to UC patients. Even though there is considerable variability in the cancer risk within this patient population, it is believed that in UC, the probability of CRC is ~2% after 10 years of disease, 8% after 20 years and 18% after 30 years. Similarly, in CD the risk estimates have been controversial, but a recent study indicated an increased overall risk of both CRC and small bowel cancer.
机译：炎症性肠病（IBD）是一组特发性肠道病症的集体术语，其代表溃疡性结肠炎（UC）和CROHN疾病（CD）。 IBD是与无核粘膜的不受控制的炎症相关的慢性复发障碍。 IBD影响美国超过100万人，每年报告大约35,000例新案件。长期以来的广泛UC和CD的患者处于发展结直肠癌（CRC）的风险增加。我们目前关于CRC危险因素的知识是基于UC患者获得的信息。然而，考虑克罗恩结肠炎结肠癌发病率的大多数研究也表明，与UC患者相比，风险增加或略低。虽然该患者群体内的癌症风险具有相当大的变异性，但据信在UC中，CRC的概率在10年后CRC的概率为约2％，20岁后8％，30岁后18％。同样，在CD中，风险估计存在争议，但最近的一项研究表明CRC和小肠癌的总体风险增加。

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