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Diagnosis of primary biliary liver diseases, overlap syndromes and changing diagnoses

机译:原发性胆汁肝病的诊断,重叠综合征和变化诊断

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Primary diseases of the biliary tract covered in this chapter are primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). Congenital diseases of the biliary tract, e.g. Caroli's disease, hypoplastic duct syndromes, biliary atresia and choledochal cysts will not be covered in this chapter. Overlap syndromes refer to chronic liver diseases which appear to have features of more than one autoimmune liver disease. Sometimes one liver disease is dominant, and other times two full-blown autoimmune liver diseases are present concurrently. Occasionally it would appear that an individual with one autoimmune disease subsequently loses the typical features of that disease and gains the features of another. Such a change in diagnosis is rare. All of these liver diseases to be discussed below probably have an autoimmune (i.e. genetically controlled) basis for their aetiology with different precipitating factors; thus it is not surprising that overlapping features may be observed.
机译:本章涉及的胆道的原发性疾病是原发性胆汁肝硬化(PBC)和原发性胆管炎(PSC)。胆道的先天性疾病,例如Caroli的疾病,假血管综合征,胆道闭锁和Choledochal囊肿不会涉及本章。重叠综合症是指慢性肝病,似乎具有多于一种自身免疫性肝病的特征。有时,一种肝病是占主导地位的,而其他次全吹过的自身免疫肝脏疾病同时存在。偶尔似乎似乎具有一个自身免疫性疾病的个体随后失去了这种疾病的典型特征,并获得了另一个疾病的特征。这种诊断的变化是罕见的。下面讨论的所有这些肝脏疾病可能具有自身免疫(即遗传控制)基础,以具有不同的促进因素的病因;因此,不令人惊讶的是,可以观察到重叠的特征。

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