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首页> 外文会议>Conference of the New Zealand Society of Animal Production >BRIEF COMMUNICATION: Expression of innate immune response genes in mammary epithelia following stimulation with lipopolysaecharide or Escherichia coli.
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BRIEF COMMUNICATION: Expression of innate immune response genes in mammary epithelia following stimulation with lipopolysaecharide or Escherichia coli.

机译：简介：用脂多利亚替代术或大肠杆菌刺激后乳腺上皮内先天免疫应答基因的表达。

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The innate immune system is essential for keeping the bovine mammary gland disease free. A number of innate immune response genes are expressed in bovine mammary epithelial cells (bMEC), suggesting it contributes to defence against pathogens (Rainard& Riollet, 2006). These responses may play a key role in determining susceptibility to mastitis. The aim of this project was to investigate the expression in bMEC of specific innate immune genes in response to Escherichia coli (E. coif) and lipopolysaecharide (LPS), the principal immunostimulatory molecule in Gram negative bacteria. These studies were performed in vitro with cultured bMEC (E. coli) and in vivo with LPS infusion in teat canals of dairy cows. A range of other inflammatory factors and milkproteins have also been surveyed in the in vivo model (Schmitz et al., 2004).
机译：先天免疫系统对于保持牛乳腺无病的必不可少。在牛乳腺上皮细胞（BMEC）中表达了许多先天的免疫反应基因，表明它有助于防御病原体（RAINARD＆RIOLLET，2006）。这些反应可能在确定对乳腺炎的易感性方面发挥关键作用。该项目的目的是探讨特定的先天免疫基因BMEC中的表达，响应于大肠杆菌（E.CoIf）和Lipopolysaecharide（LPS），革兰氏阴性细菌中的主要免疫刺激分子。这些研究是在体外进行培养的BMEC（大肠杆菌），并在乳制奶牛的乳酸奶牛中的LPS输注。在体内模型中也调查了一系列其他炎症因素和乳蛋白（Schmitz等，2004）。

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