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首页> 外文会议>International Congress of Parasitology >Primed Mucins Allow Attainment and Adhesion, But Prevent Establishment of Challenged Adult Nippostrongylus Brasiliensis in the Small Intestine in Mice
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Primed Mucins Allow Attainment and Adhesion, But Prevent Establishment of Challenged Adult Nippostrongylus Brasiliensis in the Small Intestine in Mice

机译：丙蛋白允许达到和粘附，但防止在小鼠的小肠中建立挑战成人Nippostrongylus Brasiliensis

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Adult Nippostrongylus brasiliensis were intraduodenally challenged into BALB/c mice that were given subcutaneous infection with N. brasiliensis larvae 10 days before and terminated intestinal infection. Although almost the all worms were expelled by 24 hr after challenge, substantial number of challenged worms was recovered from the small intestine up to 6 hr after challenge. Second intraduodenal challenge was performed 18 hr after the first challenge when primed mucins were actively discharged. Again secondary challenged worms were recovered in the same level to that of the first challenge. Mucins from mice infected with N. brasiliensis 8 days before was roughly isolated and implanted with adult worms into naive mice. The ratio of worms failed to establish was significantly higher than that with day 5 mucins at 24 hr after challenge. Results suggested that challenged adult N. brasiliensis once attained and adhere to their predilection sites, but failed to establish in the circumstance of primed mucins in immune mice.
机译：成人Nippostrongylus Brasiliensis颅内挑战成Balb / c小鼠，其在肠道感染前10天给予皮下感染N.Brasiliensis幼虫。虽然在挑战后，几乎所有蠕虫被驱逐出24小时，但在挑战后，从小肠中恢复了大量挑战蠕虫。第二次颅骨攻击后进行了第二次颅内挑战，在激励粘蛋白主动排出时进行了18小时。再次在第一个挑战的情况下再次恢复次要挑战蠕虫。来自小鼠的粘蛋白感染N.Brasiliensis 8天，大致被分离并植入成人蠕虫进入幼稚小鼠。蠕虫未能建立的比例明显高于攻击后24小时的第5天粘蛋白的比例。结果表明，挑战成人的成人N.Brasiliensis曾经达到并遵守其偏好的地点，但未能在免疫小鼠中的丙蛋白的情况下建立。

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