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首页> 外文会议>International Congress of Parasitology >Why Schistosomiasis Matters: The Affordability of Treating Chronic Helminthic Infection in Endemic Populations
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Why Schistosomiasis Matters: The Affordability of Treating Chronic Helminthic Infection in Endemic Populations

机译：为什么Schistosomiaisis是：在地方血症中治疗慢性蠕虫感染的负担能力

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Controversy persists over the 'significance' of schistosomiasis in poverty. This infection causes persistent inflammation, and although the range of its associated disease is well described, its average disabling effects are not well-documented or well-publicized. Accordingly, DALY weights for schistosomiasis assigned by the Global Burden of Disease Program (GBDP) were only approx 0.005 - on a par with mild diseases such as goiter. Did GBDP seriously underestimate schistosomiasis impact on global health? In an evidence-based reassessment of infection-related disability, we performed meta-analysis of health outcomes in schistosomiasis. In place of 0.5% applied by GBDP, a 2-15% disability was evident in the functional dimensions of 'average' schistosomiasis. This significantly alters projected cost-effectiveness of anti-parasite intervention, reducing cost from dollar 22 down to dollar 1- dollar 6/DALY averted, comparable with immunization (dollar 12-dollar 17/DALY) and other high-profile health initiatives. Clearly, we need to reassess the low priority given to this 'silent' pandemic of preventable disease present in many underdeveloped areas.
机译：争议仍然存在于贫困中血吸虫病的“意义”。这种感染导致持续炎症，尽管其相关疾病的范围很好地描述，但其平均禁用效果不是充分记录或良好的公布。因此，通过疾病计划（GBDP）的全球疾病（GBDP）分配的血吸虫病的Daly重量仅为0.005 - 与甲状腺素等轻度疾病的含量。 GBDP是否严重低估了血吸虫病对全球健康的影响？在基于证据的感染相关残疾的重新评估中，我们在血吸虫病中进行了对健康结果的荟萃分析。通过GBDP施加0.5％，在“平均”血吸虫病的功能尺寸中，疾病2-15％的残疾。这显着改变了抗寄生虫干预的预计成本效益，降低了美元22美元的成本1-美元6 / DALY避免，与免疫免疫（美元12美元17 / DALY）和其他高调的健康倡议相当。显然，我们需要重新评估在许多欠发达地区的这种“沉默”的可预防疾病的大会中的低优先级。

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