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首页> 外文会议>European Symposium on Computer-Aided Process Engineering >Mathematical modelling of three-dimensional cell cultures in perfusion bioreactors. Part Ⅱ
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Mathematical modelling of three-dimensional cell cultures in perfusion bioreactors. Part Ⅱ

机译：灌注生物反应器三维细胞培养物的数学建模。第二部分

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Some applications of tissue engineering require growing cells within supporting scaffolds to obtain structures with adequate functionality for in vivo implantation. A novel general dynamic mathematical model of cells growth and oxygen consumption in a three-dimensional perfusion bioreactor was recently proposed, which includes convection and diffusion, the two main transport phenomena affecting cells growth, combined with cells growth kinetics and oxygen supply. That model is used and modified here to analyze various geometric and operational configurations, including medium flow inversion, initial cell seeding procedures, and a simple vascularization model, represented by micro channels in the scaffold matrix. The significant impact on cell growth, density and density distribution within the three-dimensional scaffold is evidenced by the simulation results presented.
机译：组织工程的一些应用需要在支撑支架上生长细胞，以获得具有体内植入的足够官能度的结构。最近提出了一种新的细胞生长和氧气消耗的新型动态数学模型，包括对流和扩散，影响细胞生长的两个主要运输现象，与细胞生长动力学和氧气供应相结合。这里使用并修改该模型以分析各种几何和操作配置，包括由支架矩阵中的微通道表示的中流反转，初始细胞播种程序和简单的血管化模型。通过显示的仿真结果，证明了三维支架内的细胞生长，密度和密度分布的显着影响。

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