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首页> 外文会议>Lancefield International Symposium on Streptococci and Streptococcal Diseases >Role of the Mga regulon in the resistance of M type 4 Streptococcus pyogenes to phagocytosis
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Role of the Mga regulon in the resistance of M type 4 Streptococcus pyogenes to phagocytosis

机译：MGA调节件在M型4型链球菌的抗性的作用，吞噬细胞病

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摘要

M type 4 Streptococcus pyogenes is a frequent cause of infections, yet little is known concerning its anti-phagocytic factors. We investigated the role of the Mga regulon on growth in blood by inactivating individual genes within this regulon. Ablation of mrp4, emm4, or sof4 reduced streptococcal growth in human blood. Inactivation of enn4 had little impact on streptococcal growth in blood. Thus, expression of mrp, emm, and sof were required for optimal resistance to phagocytosis of M type 4 S. pyogenes. M proteins from class II serotypes contribute to resistance to phagocytosis by binding C4BP, a regulator of complement activation. Our data indicate that there is an additional pathway for resistance in these streptococci that is mediated by the binding of fibrinogen. Fibrinogen was required for growth of M type 4 S. pyogenes in blood and Mrp4 was the major fibrinogen-binding protein on these bacteria. Fibrmogen-Mrp interactions prevented activation of the classical pathway, thereby contributing to the ability of these streptococci to evade phagocytosis.
机译：m型4型链球菌Pyogenes是一种常心引起的感染原因，但尚是众所周知的关于其抗吞噬因子。我们调查了MGA调节局对本调节件内的个体基因灭活个体基因的作用。烧蚀MRP4，EMM4或SOF4降低人血液中的链球菌生长。 ENN4的失活对血液中的链球菌生长几乎没有影响。因此，需要MRP，EMM和SOF的表达，以获得对M型型4秒的吞噬作用的最佳抗性。来自II类血清型的M蛋白通过结合C4bp而有助于抗吞噬作用，其补充活化的调节剂。我们的数据表明，通过纤维蛋白原的结合介导的这些链球菌在这些链球菌中存在额外的途径。纤维蛋白原是在血液中的M型4秒的生长所必需的。血液和MRP4是这些细菌上的主要纤维蛋白原结合蛋白。 Fibrmogen-MRP相互作用防止了古典途径的激活，从而有助于这些链球菌逃避吞噬作用的能力。

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