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Very high sensitivity cantilever polysilicium ESI tips compatible with standard analytical chromatography fittings

机译:非常高的敏感性悬臂助理多晶硅ESI提示与标准分析色谱配件兼容

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The explosion of the field of proteomics results in a need for high-throughput analysis and consequently the automation of MS techniques. Consequently, novel emitter tips, which are more robust, reproducible and compatible with the use of robots, are required. The idea is thus to use microtechnology techniques to fabricate novel nanotips. It enhances the fabrication control and provide reproducible and nanosources and it is fully compatible with batch production. We came thus to the idea of a nib-like tip that includes a capillary slot and a point-like structure. The nib concept was validated through two generations of SU-8 prototypes, which helped us to design optimized polySi-based nib tips with smaller dimensions towards analysis enhancement.
机译:蛋白质组学领域的爆炸导致高通量分析,从而实现了MS技术的自动化。因此,需要新的发射器提示,这些发射器提示更加坚固,可再现和使用机器人的使用。因此,该思想是使用微技术技术来制造新的纳米纳米。它增强了制造控制并提供可重复和纳米源,它与批量生产完全兼容。因此,我们来了解包括毛细管槽的尖端状尖端和点状结构。通过两代的SU-8原型验证了NIB概念,这有助于我们设计优化的基于多酷酷酷的小笔尖提示,尺寸较小,朝着分析增强。

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