Ion Mobility-Mass Spectrometry Reveals the Early Assembly of Amyloid γ-Protein: The Effects of Familial Mutations A2T and A2V

机译：离子迁移率 - 质谱显示淀粉样蛋白γ-蛋白的早期组装：家族性突变A2T和A2V的影响

获取原文

页面导航

摘要
著录项
相似文献
相关主题

摘要

Early Oligomers of Amyloid β-protein as a Primary Therapeutic Target for Alzheimer's Disease: 1. The aggregation of the amyloid β-protein (Aβ) is closely related to the onset of Alzheimer's Disease (AD). Aβ is predominately found in vivo as either a 40- or 42-residue peptide (Aβ40 and Aβ42). Aβ40 is 10 times more prevalent than Aβ42, but Aβ42 aggregates more quickly and is more toxic than Aβ40. The soluble oligomers have been shown to be possible toxic species for AD.

机译：淀粉样蛋白β-蛋白的早期低聚物作为阿尔茨海默病的主要治疗靶标：1。淀粉样蛋白β-蛋白（Aβ）的聚集与阿尔茨海默病（AD）的发作密切相关。 Aβ主要以体内发现为40或42-残基肽（Aβ40和Aβ42）。 Aβ40比Aβ42普遍存在的10倍，但Aβ42比Aβ40更快地聚集并且更毒性。已显示可溶性低聚物是AD的可能有毒物种。

著录项

来源
《ASMS Conference on Mass Spectrometry and Allied Topics》|2015年||共1页
会议地点
作者
Xueyun Zheng; David Teplow; Michael T. Bowers;
展开▼
作者单位

展开▼
会议组织
原文格式 PDF
正文语种
中图分类 TB994.5-53;
关键词

相似文献

外文文献
中文文献
专利

1. Ion mobility-mass spectrometry reveals a conformational conversion from random assembly to p-sheet in amyloid fibril formation [J] . Christian Bleiholder, Nicholas F. Dupuis, Thomas Wyttenbach Nature Chemistry . 2011,第2期

机译：离子淌度质谱分析显示淀粉样蛋白原纤维形成过程中从随机组装到p-折叠的构象转换
2. Effects of the English (H6R) and Tottori (D7N) Familial Alzheimer Disease Mutations on Amyloid β-Protein Assembly and Toxicity [J] . Kenjiro Ono, Margaret Condron, David Teplow The Journal of biological chemistry . 2010,第30期

机译：英语（H6R）和鸟取（D7N）家族性阿尔茨海默病突变对淀粉样蛋白β-蛋白组装和毒性的影响
3. Effects of familial Alzheimer's disease mutations on the folding nucleation of the amyloid beta-protein. [J] . Krone MG, Baumketner A, Bernstein SL, Journal of Molecular Biology . 2008,第1期

机译：家族性阿尔茨海默氏病突变对淀粉样β蛋白折叠核的影响。
4. Ion Mobility-Mass Spectrometry Reveals the Early Assembly of Amyloid γ-Protein: The Effects of Familial Mutations A2T and A2V [C] . Xueyun Zheng, David Teplow, Michael T. Bowers ASMS Conference on Mass Spectrometry and Allied Topics . 2015

机译：离子迁移率 - 质谱显示淀粉样蛋白γ-蛋白的早期组装：家族性突变A2T和A2V的影响
5. Familial Alzheimer's disease mutations decrease gamma-secretase processing of beta amyloid precursor protein. [D] . Wiley, Jesse Carey. 2003

机译：家族性阿尔茨海默氏病突变减少了β淀粉样蛋白前体蛋白的γ-分泌酶加工。
6. Amyloid β-Protein Assembly: Differential Effects of the Protective A2T Mutation and the Recessive A2V Familial Alzheimers Disease Mutation [O] . Xueyun Zheng, Deyu Liu, Robin Roychaudhuri, -1

机译：淀粉样蛋白组装：保护性A2T突变和隐性A2V家族性阿尔茨海默氏病突变的差异作用
7. Effects of the English (H6R) and Tottori (D7N) Familial Alzheimer Disease Mutations on Amyloid β-Protein Assembly and Toxicity* [O] . Ono, Kenjiro, Condron, Margaret M., Teplow, David B. 2010

机译：英语（H6R）和鸟取（D7N）家族性阿尔茨海默氏病突变对淀粉样蛋白组装和毒性的影响*

Ion Mobility-Mass Spectrometry Reveals the Early Assembly of Amyloid γ-Protein: The Effects of Familial Mutations A2T and A2V

摘要

著录项

相似文献

相关主题

期刊订阅