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SWATH analysis of patient-derived iPSC to motor neurons for the discovery of protein network perturbations that underlie motor neuron diseases

机译：对运动神经元的患者衍生的IPSC的SWATH分析，用于发现蛋白质网络扰动的蛋白质网络扰动

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1.Preliminary analysis of iPS cell replicates was used to establish an MS-based quality control (QC) pipeline. 2.Identified commonly assayed markers of motor neuron cell cultures along with their relative protein concentrations with respect to three developmental stages, iPSC, neural rosette and mature neuron: GFAP/nestin/Ki-67/β_(III)-tubulin 3.Top 10 up/down fold changes between control and SMA mature motor neuron samples are reported 4.Report a subset of kinases with differential protein expression as iPSC differentiate into motor neuron cultures

机译：1.使用IPS细胞复制的临床分析来建立基于MS的质量控制（QC）管道。 2.鉴定三种发育阶段，IPSC，神经玫瑰花和成熟神经元的相对蛋白质浓度以及其相对蛋白质浓度的常见蛋白质浓度：GFAP / Nestin / Ki-67 /β_（III）-Tubulin 3.top 10报告了控制和SMA成熟电动机神经元样本的上/下折叠变化。报告了具有差异蛋白表达的激酶子集，因为IPSC分化为电机神经元培养物

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《ASMS Conference on Mass Spectrometry and Allied Topics》|2015年||共1页
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Andrea D. Matlock; Berhan Mandefro; Loren Ornelas; Erin Crowgey; Vidya Venkatraman; Victoria Dardov; Ronald Holewinski; Lindsay Lenaeus; Anais Sahabian; Clive Svendsen; Dhruv Sareen; Jennifer E. Van Eyk;
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1. Genome-wide RNA-seq of iPSC-derived motor neurons indicates selective cytoskeletal perturbation in Brown–Vialetto disease that is partially rescued by riboflavin [J] . Federica Rizzo, Agnese Ramirez, Claudia Compagnucci, Scientific reports. . 2017,第1期

机译：IPSC衍生的运动神经元的基因组RNA-SEQ表明棕色Vialetto疾病中的选择性细胞骨骼扰动，这些疾病被核黄素部分拯救
2. Unveiling synapse pathology in spinal bulbar muscular atrophy by genome-wide transcriptome analysis of purified motor neurons derived from disease specific iPSCs [J] . Kazunari Onodera, Daisuke Shimojo, Yasuharu Ishihara, Molecular brain . 2020,第1期

机译：通过疾病特异性IPSCS衍生的纯化电动机神经元的基因组转录组分析揭开脊柱凸形肌腱萎缩的肌肌萎缩
3. Disruption of neurofilament network with aggregation of light neurofilament protein: a common pathway leading to motor neuron degeneration due to Charcot-Marie-Tooth disease-linked mutations in NFL and HSPB1. [J] . Zhai J, Lin H, Julien JP, Human Molecular Genetics . 2007,第24期

机译：轻型神经丝蛋白聚集破坏神经丝网络：由于NFL和HSPB1中的Charcot-Marie-Tooth病相关突变，导致运动神经元变性的常见途径。
4. SWATH analysis of patient-derived iPSC to motor neurons for the discovery of protein network perturbations that underlie motor neuron diseases [C] . Andrea D. Matlock, Berhan Mandefro, Loren Ornelas, ASMS Conference on Mass Spectrometry and Allied Topics . 2015

机译：对运动神经元的患者衍生的IPSC的SWATH分析，用于发现蛋白质网络扰动的蛋白质网络扰动
5. eGFP expression under the Uchl1 promoter labels corticospinal motor neurons and a subpopulation of degeneration resistant spinal motor neurons in ALS mouse models [D] . Yasvoina, Marina V. 2013

机译：UCH11启动子标记下的EGFP表达皮质脊髓运动神经元和ALS小鼠模型中变性抗性脊柱运动神经元的亚群
6. Genome-wide RNA-seq of iPSC-derived motor neurons indicates selective cytoskeletal perturbation in Brown–Vialetto disease that is partially rescued by riboflavin [O] . Federica Rizzo, Agnese Ramirez, Claudia Compagnucci, -1

机译：iPSC来源的运动神经元的全基因组RNA序列显示布朗-维亚莱托病中的选择性细胞骨架扰动并由核黄素部分挽救
7. Unveiling synapse pathology in spinal bulbar muscular atrophy by genome-wide transcriptome analysis of purified motor neurons derived from disease specific iPSCs [O] . Kazunari Onodera, Daisuke Shimojo, Yasuharu Ishihara, 2020

机译：通过疾病特异性IPSCS衍生的纯化电动机神经元的基因组转录组分析揭开脊柱凸形肌腱萎缩的肌肌萎缩

SWATH analysis of patient-derived iPSC to motor neurons for the discovery of protein network perturbations that underlie motor neuron diseases

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