Data-independent Mass Spectrometry to Assess Secondhand Cigarette Smoke Exposure Biomarkers

机译：数据无关的质谱，评估二手卷烟烟雾曝光生物标志物

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Mounting evidence shows children's home exposure to environmental tobacco smoke (ETS) increases the risk for behavioral and cognitive issues associated with attention-deficit and other disorders. Recently, we published on a new ETS exposure model that reproduces a hyperactive-like phenotype as seen in children. Yet, other behavioral correlates and the mechanism by which ETS exposure altered juvenile behavior remain unclear. Here we employed data-independent mass spectrometry (DIA-MS) label-free quantification to assess induced changes in serum that enter the central nervous system's cerebral spinal fluid (CSF) and correlate with behavioral differences between animals. Findings are expected to shed light on mediating factors underlying ETS-induced behavioral perturbation with diagnostic potential as biomarkers relating exposure with juvenile deficits.

机译：安装证据显示儿童的家庭烟草烟雾（ETS）的接触会增加与关注赤字和其他疾病相关的行为和认知问题的风险。最近，我们发表于新的ETS曝光模型，可在儿童中再现多活跃的表型。然而，其他行为相关性和ETS暴露改变的少年行为的机制仍不清楚。在这里，我们使用与数据无关的质谱（Dia-MS）无标记定量来评估进入中枢神经系统脑脊髓（CSF）的血清中的诱导变化，并与动物之间的行为差异相关。预计调查结果将阐明ETS诱导的行为扰动的介导因子与诊断潜力作为与少年赤字接触的生物标志物的诊断潜力。

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《ASMS Conference on Mass Spectrometry and Allied Topics》|2016年|1CD|共3页
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Pretal Muldoon; Jillian Stafflinger; Andrew Ottens;
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1. The Secondhand Smoke Exposure Scale (SHSES): A hair nicotine validated tool for assessing exposure to secondhand smoke among elderly adults in primary care [J] . Constantine I. Vardavas, Israel Agaku, Filippos Filippidis, Tobacco Prevention and Cessation . 2017,第April期

机译：二手烟暴露量表（SHSES）：经过头发尼古丁验证的工具，用于评估初级保健中老年人的二手烟暴露量
2. A study to evaluate the effect on Mouth Level Exposure and biomarkers of exposure estimates of cigarette smoke exposure following a forced switch to a lower ISO tar yield cigarette. [J] . Shepperd CJ, Eldridge AC, Errington G, Regulatory Toxicology and Pharmacology: RTP . 2011,第3Suppla1期

机译：评估强制转换为较低ISO焦油产量的卷烟后，对口中暴露量的影响以及卷烟烟雾接触量估计值生物标志物的研究。
3. A study to evaluate the effect on Mouth Level Exposure and biomarkers of exposure estimates of cigarette smoke exposure following a forced switch to a lower ISO tar yield cigarette. [J] . Shepperd CJ, Eldridge AC, Errington G, Regulatory Toxicology and Pharmacology: RTP . 2011,第3Suppla1期

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4. Data-independent Mass Spectrometry to Assess Secondhand Cigarette Smoke Exposure Biomarkers [C] . Pretal Muldoon, Jillian Stafflinger, Andrew Ottens ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：数据无关的质谱，评估二手卷烟烟雾曝光生物标志物
5. Levels of biomarkers of secondhand smoke exposure and risk of lung cancer in urban neversmokers [D] . Payulert, Catherine. 2014

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6. The Secondhand Smoke Exposure Scale (SHSES): A hair nicotine validated tool for assessing exposure to secondhand smoke among elderly adults in primary care [O] . Constantine Vardavas, Israel Agaku, Filippos Filippidis, 2017

机译：二手烟暴露量表（SHSES）：经过头发尼古丁验证的工具用于评估初级保健中老年人的二手烟暴露量
7. Assessing secondhand and thirdhand tobacco smoke exposure in Canadian infants using questionnaires, biomarkers, and machine learning [O] . Jaclyn Parks, Kathleen E. McLean, Lawrence McCandless, 2021

机译：使用问卷，生物标志物和机器学习在加拿大婴儿中评估二手和第三手烟草烟雾暴露

Data-independent Mass Spectrometry to Assess Secondhand Cigarette Smoke Exposure Biomarkers

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