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首页> 外文会议>ASMS Conference on Mass Spectrometry and Allied Topics >Uncovering Cryptic Secondary Metabolites from Aspergillus nidulans with HDAC Inhibition
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Uncovering Cryptic Secondary Metabolites from Aspergillus nidulans with HDAC Inhibition

机译：从曲霉抑制中揭开曲霉菌的神秘次生代谢物

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Among microbes, fungi have an immense store of cryptic secondary metabolites. Often these small molecules can be repurposed as probes for studying biology or as pharmaceuticals. The genes that encode secondary metabolic machinery are often genomically colocalized into biosynthetic gene clusters. Because of the immense energetic costs that goes into producing the biosynthetic pathway and its products, strict control over their expression is necessary in the competitive environments that microbes occupy. In fungi, one key means of regulating these gene clusters is by repressively condensing the genes into heterochromatin through reversible histone deacetylation.
机译：在微生物中，真菌有一个巨大的神秘次生代谢物储存。通常，这些小分子可以被重新归类为研究生物学或药物的探针。编码次级代谢机制的基因通常是基因组上叠在生物合成基因簇中。由于生产生物合成途径及其产品的巨大能量成本，在微生物占据的竞争环境中，必须严格控制其表达。在真菌中，通过可逆组蛋白脱乙酰化将基因压缩到异铬胺中，调节这些基因簇的一种关键方法。

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