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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Epigenetic modulation of secondary metabolite profiles in Aspergillus calidoustus and Aspergillus westerdijkiae through histone deacetylase (HDAC) inhibition by vorinostat
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Epigenetic modulation of secondary metabolite profiles in Aspergillus calidoustus and Aspergillus westerdijkiae through histone deacetylase (HDAC) inhibition by vorinostat

机译：曲霉血清菌和Westerdijkiae通过组蛋白脱乙酰酶（HDAC）抑制血管霉菌患者次生代谢物谱的表观遗传调节

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摘要

The effects of epigenetic modulation on secondary metabolite biosynthesis were investigated with five Aspergillus species cultured in the presence of either the DNA methyltransferase inhibitor 5-azacitidine or the histone deacetylase inhibitor vorinostat. With Aspergillus calidoustus and Aspergillus westerdijkiae, fermentation in the presence of vorinostat (100 mu M) induced significant changes in secondary metabolite profile with examples of both induction and repression. We identified putative biosynthetic gene clusters for emericellamide in A. calidoustus and ochratoxin in A. westerdijkiae. A substantial induction in production levels was observed for two secondary metabolites: the diketopiperazine alkaloid phenylahistin in A. calidoustus and the polyketide penicillic acid in A. westerdijkiae, indicating the potential of epigenetic regulation for the activation of silent fungal biosynthetic pathways.
机译：在DNA甲基转移酶抑制剂5-氮杂氨酸的存在下培养的五种葡萄霉菌或组蛋白脱乙酰化酶抑制剂vorinostat，研究了表观遗传调节对次生代谢物生物合成的影响。 含有曲霉属Calidoustus和Aspergillus Westerdijkiae，在vorinostat（100 mu m）存在下发酵诱导次级代谢物型的显着变化，与诱导和抑制的例子。 我们在A. Westerdijkiae在A. Calidoustus和Ochratoxin中识别出emiceChetamide的推定的生物合成基因簇。 在两种次级代谢物中观察到生产水平的大量诱导：A.·韦斯特·德里奇基省A中的水哌嗪生物碱酚醛酚素和聚酮化酮青霉酸，表明围绕静音真菌生物合成途径的表观遗传调控的潜力。

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