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Automated Online Monitoring and Quality Control of Glycan Profiles from Cetuximab (F_d) and Trastuzumab (F_c) using IdeS Digestion and Subunit Separation in Combination with Ultrahigh-Resolution QTOF Mass Spectrometric Analysis

机译：使用IDE消化和亚基分离与超高分辨率QTOF质谱分析的自动化在Cetuximab（F_D）和Trastuzumab（F_C）的在线监测和质量控制

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A platform to automatically perform mAb digestion with F_c- and L_c/F_d subunit purification from an mammalian cell cultivation with subsequent MS analysis was established. Rapid MS measurement at full sensitivity and resolution can determine quality attributes such as the glycoprofile on a mAb subunit.

机译：建立了用随后的MS分析从哺乳动物细胞培养中自动进行MAB消化的平台与哺乳动物细胞培养。充分敏感性和分辨率的快速MS测量可以确定MAB亚基上的质量属性，例如甘替替替替替替替替替洛。

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《ASMS Conference on Mass Spectrometry and Allied Topics》|2016年|1CD|共1页
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D. Erlandsson; S. Bjork; M. Hedstrom; F. Olsson; E. Belau; A. Wiechmann; C. Evans; G. Tremintin; J. Wood; D. Suckau; W. Jabs;
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1. Filter-Aided N?Glycan Separation (FANGS): A Convenient Sample Preparation Method for Mass Spectrometric N?Glycan Profiling [J] . Salina Abdul Rahman, Ed Bergstro?m, Christopher J. Watson, Journal of proteome research . 2014,第3期

机译：过滤器辅助的N-聚糖分离（FANGS）：一种方便的质谱法制备N-聚糖的样品制备方法
2. Automated integration of monolith-based protein separation with on-plate digestion for mass spectrometric analysis of esophageal adenocarcinoma human epithelial samples. [J] . Yoo C, Zhao J, Pal M, Electrophoresis: The Official Journal of the International Electrophoresis Society . 2006,第18期

机译：基于整体的蛋白质分离与板上消化的自动化整合，用于食道腺癌人上皮样品的质谱分析。
3. Integrated Platform for Proteome Profiling with Combination of Microreversed Phase Based Protein and Peptide Separation via Online Solvent Exchange and Protein Digestion [J] . Huiming Yuan, Yuan Zhou, Simin Xia, Analytical chemistry . 2012,第11期

机译：蛋白质组分析的集成平台，结合微反相蛋白质和通过在线溶剂交换和蛋白质消化的肽分离
4. Automated Online Monitoring and Quality Control of Glycan Profiles from Cetuximab (F_d) and Trastuzumab (F_c) using IdeS Digestion and Subunit Separation in Combination with Ultrahigh-Resolution QTOF Mass Spectrometric Analysis [C] . D. Erlandsson, S. Bjork, M. Hedstrom, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：使用IDE消化和亚基分离与超高分辨率QTOF质谱分析的自动化在Cetuximab（F_D）和Trastuzumab（F_C）的在线监测和质量控制
5. Filter-Aided N-Glycan Separation(FANGS): A Convenient Sample Preparation Method for Mass Spectrometric N-Glycan Profiling [O] . Salina Abdul Rahman, Ed Bergström, Christopher J. Watson, -1

机译：过滤辅助的N-聚糖分离（FANGS）：用于质谱法N-聚糖分析的便捷样品制备方法
6. Automated integration of monolith-based protein separation with on-plate digestion for mass spectrometric analysis of esophageal adenocarcinoma human epithelial samples [O] . Chul Yoo, Jia Zhao, Manoj Pal, 2006

机译：单层蛋白质分离的自动整合与板材消化，用于食管腺癌人上皮样品的质谱分析

Automated Online Monitoring and Quality Control of Glycan Profiles from Cetuximab (F_d) and Trastuzumab (F_c) using IdeS Digestion and Subunit Separation in Combination with Ultrahigh-Resolution QTOF Mass Spectrometric Analysis

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