A Validated Multiplex Assay for the Quantification of Tryptophan and Four of its Catabolites in Human Plasma and Cerebrospinal Fluid

机译：用于定量色氨酸和其四个分解粘剂中的验证多重测定，在人血浆和脑脊液中

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Induction of indolamine 2,3-dioxygenase (as exhibited during neuroinflammation) leads to an increased catabolism of L-tryptophan into L-kynurenine, which is further metabolized to the neuroactive quinolinic acid (via 3-hydroxy-L-kynurenine) and kynurenic acid. In order to investigate the relationship between expression levels of tryptophan and its catabolites and disorders such as depression or Alzheimer's disease, an assay was needed that allows the quantification of the analytes of interest with sufficient sensitivity and analytical robustness.

机译：诱导吲哚胺2,3-二恶英酶（如神经炎症期间表现）导致L-色氨酸进入L-knynurenine的分解代谢，其进一步代谢到神经活性喹啉酸（通过3-羟基-1-kynurenine）和鸡蛋酸。为了探讨色氨酸的表达水平与其分解粘剂和抑郁症或阿尔茨海默病等疾病之间的关系，需要一种测定，允许用足够的敏感性和分析稳健性定量利益分析物。

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《ASMS Conference on Mass Spectrometry and Allied Topics》|2016年|1CD|共1页
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Joachim Hoke; Andre Liesener; Stefan Blech;
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中图分类 TB994.5-53;
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A Validated Multiplex Assay for the Quantification of Tryptophan and Four of its Catabolites in Human Plasma and Cerebrospinal Fluid

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