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Comparison of projections of the dorsal and median raphe nuclei, with some functional considerations

机译：多核和中位数核的投影比较，具有一些功能考虑因素

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It is well established that the brainstem contains discrete groups of serotonin-containing neurons with extensive axonal processes that distribute throughout the neuroaxis. Serotonergic neurons have been implicated in a range of functions including sleep/wakefulness, feeding, affect/ emotion, thermoregulation, and cognitive behaviors. We describe the projections and some functional properties of the two major serotonergic cell groups of the brain, the dorsal raphe (DR) and the median raphe (MR) nuclei. DR fibers distribute widely throughout the forebrain to dopamine-containing nuclei of the ventral midbrain, the lateral hypothalamus, the midline thalamus, amygdala, the dorsal and ventral striatum and adjoining regions of the basal forebrain, and most of the cortex. By contrast with DR, MR is a midline/paramidline system of projections. Specifically, MR fibers mainly distribute to forebrain structures lying on or close to the midline including the medial mammillary and supramammillary nuclei, posterior and perifomical nuclei of the hypothalamus, midline and intralaminar nuclei of the thalamus, lateral habenula, medial zona incerta, diagonal band nuclei, septum and hippocampus. Overall, MR projections to the cortex are light. With few exceptions, DR and MR project to separate, non-overlapping regions of the forebrain - or, in effect, DR and MR share the serotonergic innervation of the forebrain. We discuss roles for DR in sleep/ wake control, feeding/appetite and mood/affect, and for MR in the control of electroencephalo-graphic (EEG) activity of the hippocampus - or states of hippocampal EEG desynchronization. ? 2007 Published by Elsevier B.V
机译：很好地确定，脑干含有含含血清素的神经元的离散组，具有广泛的轴突过程，可在整个神经内分布。 Serotonergic神经元在一系列功能中涉及，包括睡眠/醒来，喂养，影响/情绪，热调节和认知行为。我们描述了脑，背部拉皮（DR）和中位罗基（MR）核的两种主要血清奈莫罗语细胞组的预测和一些功能性质。博士纤维在整个前脑中广泛分布到腹侧中脑的多巴胺核，侧面下丘脑，中线丘脑，杏仁菌，背侧和腹侧纹状体以及基础前脑的邻近区域，以及大部分皮质。通过与DR对比，MR是一个中线/ PARAMIDLINE系统的预测系统。具体而言，MR纤维主要分布于躺在中线或接近中线的前脑结构，包括丘脑，中线和脑内核，中线和胰蛋白核核，横向湿润，内侧Zona incerta，对角线带核的中间乳腺和神经核细胞核，隔膜和海马。总的来说，对皮质的MR投影是光线。少数例外，博士和MR项目分开，非重叠的前脑区域 - 或实际上，博士和先生共享前脑的血清正式原理。我们讨论了睡眠/唤醒控制，喂养/食欲和情绪/影响的博士的角色，以及用于控制海马的脑电图 - 图形（EEG）活性的MR或海马脑电图的状态。还是2007年由elestvier b.v发布

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