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Acyclic nucleoside phosphonates as a new class of anti-malarial compounds: Inhibition of Plasmodium falciparum hypoxanthine-guahine-xanthine phosphoribosyltransferase by 9-2-(2-phosphonoethoxy)ethyl-purines and their branched derivatives

机译：环状核苷膦酸盐作为一种新的抗疟疾化合物：抑制疟原虫脱氧黄嘌呤 - 黄嘌呤 - 黄嘌呤磷酰基转移酶的抑制作用9- 2-（2-膦酰基乙氧基）乙基 - 杂物和其支化衍生物

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The majority of lethal cases of malaria are caused by Plasmodium falciparum (Pf). These protozoan parasites can only produce purine nucleotides from the bases obtained from their host, while mammals are able to synthesize purine derivatives de novo as well as by salvage of preformed bases. Hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT) is the key enzyme of purine salvage pathway, its activity has been shown to be essential for the survival of the parasite and so it represents a suitable drug target.

机译：大多数疟疾病例的疟疾病例是由疟原虫（PF）引起的。这些原生动物寄生虫只能从其宿主获得的碱中产生嘌呤核苷酸，而哺乳动物能够合成嘌呤衍生物DE NOVO以及通过预成型碱的挽救。缺氧 - 鸟嘌呤 - 黄嘌呤磷纤维基转移酶（HGXPRT）是嘌呤救生途径的关键酶，其活性已显示对寄生虫的存活至关重要，因此它代表了合适的药物靶标。

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《European Symposium on Organic Chemistry》|2009年||共1页
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Dana Hockova; Antonin Holy; Dianne T. Keough;
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1. Synthesis of branched 9-(2-(2-phosphonoethoxy)ethyl)purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase. [J] . Hockova D, Holy A, Masojidkova M Bioorganic and medicinal chemistry . 2009,第17期

机译：新型的无环核苷膦酸酯类的支化9-（2-（2-（膦酰基乙氧基）乙基）嘌呤的合成，可抑制恶性疟原虫次黄嘌呤-鸟嘌呤-黄嘌呤磷酸核糖基转移酶。
2. Synthesis of novel N-branched acyclic nucleoside phosphonates as potent and selective inhibitors of human, plasmodium falciparum and plasmodium vivax 6-oxopurine phosphoribosyltransferases [J] . Hocková D., Keough D.T., Janeba Z., Journal of Medicinal Chemistry . 2012,第13期

机译：新型N分支无环核苷膦酸酯的合成，可作为人，恶性疟原虫和间日疟原虫6-氧嘌呤磷酸核糖基转移酶的强效和选择性抑制剂
3. Aza-acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group As Inhibitors of the Human, Plasmodium falciparum and vivax 6-Oxopurine Phosphoribosyltransferases and Their Prodrugs As Antimalarial Agents [J] . Keough Dianne T., Hockova Dana, Janeba Zlatko, Journal of Medicinal Chemistry . 2015,第2期

机译：含第二个膦酸酯基团的氮杂无环核苷膦酸酯作为人类疟原虫和恶性疟原虫6-氧嘌呤磷酸核糖基转移酶及其前药的抑制剂，作为抗疟剂
4. Acyclic nucleoside phosphonates as a new class of anti-malarial compounds: Inhibition of Plasmodium falciparum hypoxanthine-guahine-xanthine phosphoribosyltransferase by 9-2-(2-phosphonoethoxy)ethyl-purines and their branched derivatives [C] . Dana Hockova, Antonin Holy, Dianne T. Keough European Symposium on Organic Chemistry . 2009

机译：环状核苷膦酸盐作为一种新的抗疟疾化合物：抑制疟原虫脱氧黄嘌呤 - 黄嘌呤 - 黄嘌呤磷酰基转移酶的抑制作用9- 2-（2-膦酰基乙氧基）乙基 - 杂物和其支化衍生物
5. Investigating the role of Plasmodium falciparum equilibrative nucleoside transporter 1 in malarial physiology and anti-malarial activity. [D] . Riegelhaupt, Paul M. 2010

机译：研究恶性疟原虫平衡核苷转运蛋白1在疟疾生理和抗疟疾活性中的作用。
6. Acyclic nucleoside phosphonates with a branched 2-(2-phosphonoethoxy)ethyl chain: Efficient synthesis and antiviral activity [O] . Dana Hocková, Antonín Holý, Graciela Andrei, -1

机译：具有分支的2-（2-膦酰基乙氧基）乙基链的无环核苷膦酸酯：高效合成和抗病毒活性
7. Antimalarial activity of prodrugs of N-branched acyclic nucleoside phosphonate inhibitors of 6-oxopurine phosphoribosyltransferases [O] . Dana Hocková, Zlatko Janeba, Lieve Naesens, 2015

机译：6-氧化磷酸磷基三碱基酶的N-支链无核苷核苷抑制剂前药的抗疟活性

Acyclic nucleoside phosphonates as a new class of anti-malarial compounds: Inhibition of Plasmodium falciparum hypoxanthine-guahine-xanthine phosphoribosyltransferase by 9-2-(2-phosphonoethoxy)ethyl-purines and their branched derivatives

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