首页> 外文会议>International Mass Spectrometry Conference >UPLC/MS method for determination of panel of neurotransmitters in rat cerebrospinal fluid: application to the rat model for tauopathy

【24h】

UPLC/MS method for determination of panel of neurotransmitters in rat cerebrospinal fluid: application to the rat model for tauopathy

机译：UPLC / MS方法，用于测定大鼠脑脊液中神经递质的面板：施经胁迫对大鼠模型的应用

获取原文

页面导航

摘要
著录项
相似文献
相关主题

摘要

In this study, we developed and further validated new UPLC/MS method using a benzoyl chloride as pre-column derivatization reagent for the simultaneous determination of 10 NT and metabolites in rat CSF. The developed method is easy, highly sensitive and requires only small volume of CSF sample. The concentrations determined by the current method are in the same order of magnitude as in the literature. Using this method we analysed neurotransmitters and metabolites in the CSF of transgenic rat model for human tauopathy.

机译：在该研究中，我们使用苯甲酰氯作为预柱衍生化试剂进行了新的UPLC / MS方法，用于同时测定大鼠CSF中的10 NT和代谢物。开发的方法很容易，高度敏感，只需要少量的CSF样品。由当前方法确定的浓度与文献中相同的数量级。使用该方法，我们分析了人身疏松症转基因大鼠模型CSF中的神经递质和代谢物。

著录项

来源
《International Mass Spectrometry Conference》|2014年||共1页
会议地点
作者
Andrej Kovac; Zuzana Somikova; Norbert Zilka; Michal Novak;
展开▼
作者单位

展开▼
会议组织
原文格式 PDF
正文语种
中图分类分析化学;
关键词

相似文献

外文文献
中文文献
专利

1. Liquid chromatography-tandem mass spectrometry method for determination of panel of neurotransmitters in cerebrospinal fluid from the rat model for tauopathy [J] . Andrej Kovac, Zuzana Somikova, Norbert Zilka, Talanta: The International Journal of Pure and Applied Analytical Chemistry . 2014,第Null期

机译：液相色谱-串联质谱法测定tauopathy大鼠模型中脑脊液中神经递质的含量
2. Development of an UPLC–MS/MS method for quantification of Avitinib (AC0010) and its five metabolites in human cerebrospinal fluid: Application to a study of the blood-brain barrier penetration rate of non-small cell lung cancer patients [J] . Weicong Wang, Xin Zheng, Hanping Wang, Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis . 2017,第期

机译：用于量化Avitinib（AC0010）的UPLC-MS / MS方法及其五种代谢物中的人脑脊髓液中的五种代谢物：应用于非小细胞肺癌患者的血脑屏障渗透率研究
3. Diethylation Labeling Combined with UPLC/MS/MS for Simultaneous Determination of a Panel of Monoamine Neurotransmitters in Rat Prefrontal Cortex Microdialysates [J] . Chengjie Ji, Wenlin Li, Xiao-dan Ren, Analytical chemistry . 2008,第23期

机译：二乙基化标记结合UPLC / MS / MS同时测定大鼠前额叶皮层微透析液中一组单胺神经递质
4. UPLC/MS method for determination of panel of neurotransmitters in rat cerebrospinal fluid: application to the rat model for tauopathy [C] . Andrej Kovac, Zuzana Somikova, Norbert Zilka, International Mass Spectrometry Conference . 2014

机译：UPLC / MS方法，用于测定大鼠脑脊液中神经递质的面板：施经胁迫对大鼠模型的应用
5. Development and validation of UPLC/MS/MS methods for quantification of gangliosides in the clinical study of ganglioside GM3 synthase deficiency. [D] . Huang, Qianyang. 2016

机译：神经节苷脂GM3合酶缺乏症临床研究中用于定量神经节苷脂的UPLC / MS / MS方法的开发和验证。
6. Development of a UPLC-MS/MS Method for Simultaneous Determination of Six Flavonoids in Rat Plasma after Administration of Maydis stigma Extract and Its Application to a Comparative Pharmacokinetic Study in Normal and Diabetic Rats [O] . Bin-Bin Wei, Zai-Xing Chen, Ming-Yan Liu, 2017

机译：建立UPLC-MS / MS方法同时测定柱头Maydis柱提取物后大鼠血浆中六种类黄酮的含量及其在正常和糖尿病大鼠中的药代动力学比较研究中的应用
7. Development and application of a UPLC-MS/MS method for simultaneous determination of fenofibric acid and berberine in rat plasma: application to the drug-drug pharmacokinetic interaction study of fenofibrate combined with berberine after oral administrati [O] . Guofei Li, Fan Yang, Mei Liu, 2016

机译：大鼠血浆同时测定UNENIBRIC酸和小檗碱的UPLC-MS / MS法的开发和应用：对口腔管理后小檗碱联合小檗碱药物药代动力学相互作用研究的应用

UPLC/MS method for determination of panel of neurotransmitters in rat cerebrospinal fluid: application to the rat model for tauopathy

摘要

著录项

相似文献

相关主题

期刊订阅