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Understanding the molecular basis of (R/W)9 cell penetrating peptide (CPP) effect on the phenotype of EF cells, a model cell line for Ewing sarcoma.

机译：理解（R / W）9细胞穿透肽（CPP）对EF细胞表型的分子基础，用于均匀肉瘤的模型细胞系。

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Quite surprisingly the significant changes of EF tumoral cells phenotype observed after incubation with (R/W)9 CPP are not correlating with deep modifications in protein expression profiles: only a few proteins expression levels have been modulated. The tumoral phenotype reversion could thus be due to more subtle changes such as post-translational modifications of the proteins. We are thus currently investigating phosphorylation using a quantitative and phosphoproteomics approach. To see if the few changes in protein expression correlate with the observed phenotype we are also currently assessing the effect on the proteome of other CPPs which do not remodel the actin cytoskeleton.

机译：相当令人惊讶地，与（R / W）9 CPP孵育后观察到的EF肿瘤细胞表型的显着变化不与蛋白质表达谱的深层修饰相关：仅调节少数蛋白质表达水平。因此，肿瘤表型回归可能是由于更细微的变化，例如蛋白质的翻译后修饰。因此，我们目前正在使用定量和磷蛋白酶方法来研究磷酸化。为了看看蛋白质表达的少数变化与观察到的表型相关，我们目前还在评估对不重塑肌动蛋白细胞骨架的其他CPP的蛋白质组的影响。

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《International Mass Spectrometry Conference》|2014年||共2页
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Severine Clavier; Sandrine Sagan; Gerard Bolbach; Emmanuelle Sachon;
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中图分类分析化学;
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1. Proteomic comparison of the EWS-FLI1 expressing cells EF with NIH-3T3 and actin remodeling effect of (R/W)"9 cell-penetrating peptide [J] . Séverine Clavier, Fran?oise Illien, Sandrine Sagan, EuPA Open Proteomics . 2016,第11期

机译：EWS-FLI1表达细胞EF与NIH-3T3的蛋白质组学比较和（R / W）“ 9细胞穿透肽的肌动蛋白重塑作用
2. CYTOPROTECTIVE ACTION OF SOLUBLE HEME OXYGENASE-1-CELL PENETRATING PEPTIDE (SHO-1-CPP) OBSERVED IN IN VITRO HEPATIC ISCHEMIA-REPERFUSION INJURY (IRI) MODELS [J] . Venkatachalam A., Ray A., Maclean J., Transplant international : . 2016,第Suppla2期

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3. Antimicrobial cell penetrating peptides with bacterial cell specificity: pharmacophore modelling, quantitative structure activity relationship and molecular dynamics simulation [J] . Mbuso Faya, Rahul S. Kalhapure, Dinesh Dhumal, Journal of Biomolecular Structure and Dynamics . 2019,第9a10期

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4. Understanding the molecular basis of (R/W)9 cell penetrating peptide (CPP) effect on the phenotype of EF cells, a model cell line for Ewing sarcoma. [C] . Severine Clavier, Sandrine Sagan, Gerard Bolbach, International Mass Spectrometry Conference . 2014

机译：理解（R / W）9细胞穿透肽（CPP）对EF细胞表型的分子基础，用于均匀肉瘤的模型细胞系。
5. Characterization of the TAT cell penetrating peptide and directed evolution of new cell penetrating peptides for protein and nucleotide delivery to neuronal-like cells. [D] . Gao, Shan. 2009

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6. Considerations on the Rational Design of Covalently Conjugated Cell-Penetrating Peptides (CPPs) for Intracellular Delivery of Proteins: A Guide to CPP Selection Using Glucarpidase as the Model Cargo Molecule [O] . Yasaman Behzadipour, Shiva Hemmati 2019

机译：合理设计共价共轭细胞穿透肽（CPPs）进行细胞内传递蛋白的思考：使用葡糖苷酶作为模型货物分子选择CPP的指南
7. Considerations on the Rational Design of Covalently Conjugated Cell-Penetrating Peptides (CPPs) for Intracellular Delivery of Proteins: A Guide to CPP Selection Using Glucarpidase as the Model Cargo Molecule [O] . 2019

机译：关于共价缀合的细胞穿透肽（CPP）的理性设计考虑，用于细胞内递送蛋白质：使用葡萄糖糖酶作为模型货物分子的CPP选择指南

Understanding the molecular basis of (R/W)9 cell penetrating peptide (CPP) effect on the phenotype of EF cells, a model cell line for Ewing sarcoma.

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