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CONVERSION OF COENZYME A THIOESTERS BY NATIVE CHEMICAL LIGATION - A NEW APPROACH FOR CHARACTERIZING AN IMPORTANT CLASS OF BIOMOLECULES

机译：天然化学结扎辅酶α硫酯 - 一种表征重要种类的新方法

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Acyl-coenzyme A esters (acyl-CoAs) are very important biomolecules which play a central role in different metabolic processes, including β-oxidation of fatty acids, amino acid degradation and the citric acid cycle. Although numerous techniques for the analysis of acyl-CoAs have been developed, a straightforward approach for the unambiguous characterization of isomeric acyl-CoAs is still lacking.

机译：酰基 - 辅酶酯（酰基-COA）是非常重要的生物分子，其在不同代谢过程中起核心作用，包括脂肪酸的β-氧化，氨基酸降解和柠檬酸循环。虽然已经开发了许多用于分析酰基CoAs的技术，但仍然缺乏对异构酰基-CAA的明确表征的直接方法。

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《International Mass Spectrometry Conference》|2018年|p628-1245|共2页
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作者
Nevenka Cakic; Heinz Wilkes;
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正文语种
中图分类分析化学;
关键词
Coenzyme A thioesters; native chemical ligation; fragmentation patterns; chiral separation;

机译：辅酶A硫代锡;原生化学结扎;碎片模式;手性分离;

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专利

1. Solid-Phase Synthesis of Peptide C-Terminal Thioesters by Fmoc/t-Bu Chemistry; Fmoc-Based Synthesis of Peptide-α-Thioesters: Application to the Total Chemical Synthesis of a Glycoprotein by Native Chemical Ligation [J] . Anna Bernardi, Leonardo Manzoni Chemtracts . 2000,第9期

机译：用Fmoc / t-Bu化学方法固相合成肽C-末端硫代酸酯;基于Fmoc的肽-α-硫代酸酯的合成：通过天然化学连接在糖蛋白的总化学合成中的应用
2. An Efficient Fmoc-SPPS Approach for the Generation of Thioester Peptide Precursors for Use in Native Chemical Ligation [J] . Juan B.Blanco-Canosa, Philip E.Dawson Angewandte Chemie . 2008,第36期

机译：一种高效的Fmoc-SPPS方法可生成用于天然化学连接的硫酯肽前体
3. Semi-synthesis of murine prion protein by native chemical ligation and chemical activation for preparation of polypeptide--thioester [J] . Shi Lei, Chen Huai, Zhang Si-Yu, Journal of peptide science: An official publication of the European Peptide Society . 2017,第6期

机译：用途化学结扎和化学活化制备多肽 - 硫酯的半合成鼠朊蛋白
4. CONVERSION OF COENZYME A THIOESTERS BY NATIVE CHEMICAL LIGATION - A NEW APPROACH FOR CHARACTERIZING AN IMPORTANT CLASS OF BIOMOLECULES [C] . Nevenka Cakic, Heinz Wilkes International Mass Spectrometry Conference . 2018

机译：天然化学结扎辅酶α硫酯 - 一种表征重要种类的新方法
5. The synthesis of aryl propanoid coenzyme A thioesters and Taxol analogs for biochemical investigation of a Taxol pathway acyltransferase. [D] . Sanyal, Sanjit. 2007

机译：芳基丙烷类辅酶A硫酯和紫杉醇类似物的合成，用于紫杉醇途径酰基转移酶的生化研究。
6. An efficient Fmoc-SPPS approach for the generation of thioester peptide precursors for use in native chemical ligation [O] . Dr. Juan B. Blanco-Canosa, Dr. Philip E. Dawson -1

机译：一种有效的Fmoc-SPPS方法用于生成硫酯肽前体以用于天然化学连接
7. Optimisation of chemical protein cleavage for erythropoietin semi-synthesis using native chemical ligation† †Electronic supplementary information (ESI) available: MS and LC-MS characterisation for thioester 2 and the M54L EPO mutant. See DOI: 10.1039/b811501j Click here for additional data file. [O] . Richardson, Jonathan P., Macmillan, Derek 2008

机译：使用天然化学连接优化促红细胞生成素半合成的化学蛋白质裂解† †可用电子补充信息（ESI）：硫酯2和M54L EPO突变体的MS和LC-MS表征。参见DOI：10.1039 / b811501j 单击此处获取其他数据文件。
8. Chemoselective Attachment of Biologically Active Proteins to Surfaces by Native Chemical Ligation [R] . Camarero, J. A., Cheung, C. L., Coleman, M., 2003

机译：通过天然化学连接将生物活性蛋白质化学选择性附着于表面

CONVERSION OF COENZYME A THIOESTERS BY NATIVE CHEMICAL LIGATION - A NEW APPROACH FOR CHARACTERIZING AN IMPORTANT CLASS OF BIOMOLECULES

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