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IMPROVING COVERAGE IN TRANSMEMBRANE DOMAINS OF INTEGRAL MEMBRANE PROTEINS WITH ULTRA-VIOLET PHOTODISSOCIATION

机译：用超紫光度光度分析改善整体膜蛋白跨膜结构域的覆盖率

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The most common structural feature of membrane proteins is the bilayer embedded alpha helix. Mass spectrometric coverage during dissociation experiments is frequently limited due to lack of charged residues and retention of structure in the gas phase. In this presentation we explore new strategies for improving coverage in transmembrane domains using FTICR and other high-resolution instruments, including ultra-violet photodissociation (UVPD).

机译：膜蛋白最常见的结构特征是双层嵌入α螺旋。在解离实验期间的质谱覆盖通常由于缺乏带电残余物和气相中的结构保留而受到限制。在本演示文献中，我们利用FTICR和其他高分辨率仪器探索改善跨膜结构域中的覆盖率的新策略，包括紫外线光度蚀刻（UVPD）。

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《International Mass Spectrometry Conference》|2018年|p1-627|共2页
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作者
Julian Whitelegge;
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正文语种
中图分类分析化学;
关键词
membrane protein; FTMS; electron-capture dissociation; electron-transfer dissociation;

机译：膜蛋白;FTMS;电子捕获解离;电子转移解离;

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专利

1. Increased coverage in the transmembrane domain with activated-ion electron capture dissociation for top-down Fourier-transform mass spectrometry of integral membrane proteins [J] . Zabrouskov V, Whitelegge JP Journal of proteome research . 2007,第6期

机译：自上而下的傅里叶变换质谱法对完整膜蛋白的活化离子电子捕获解离提高跨膜结构域的覆盖率
2. Toward the complete membrane proteome: high coverage of integral membrane proteins through transmembrane peptide detection. [J] . Fischer F, Wolters D, Rogner M, Molecular & cellular proteomics: MCP . 2006,第3期

机译：迈向完整的膜蛋白质组学：通过跨膜肽检测，高覆盖完整膜蛋白。
3. Transmembrane domains participate in functions of integral membrane proteins [J] . T Ramasarma Indian Journal of Biochemistry & Biophysics . 1996,第1期

机译：跨膜结构域参与整合膜蛋白的功能
4. IMPROVING COVERAGE IN TRANSMEMBRANE DOMAINS OF INTEGRAL MEMBRANE PROTEINS WITH ULTRA-VIOLET PHOTODISSOCIATION [C] . Julian Whitelegge International Mass Spectrometry Conference . 2018

机译：用超紫光度光度分析改善整体膜蛋白跨膜结构域的覆盖率
5. Specific interactions between transmembrane alpha-helices: Their role in the oligomerization of integral membrane proteins [D] . Lemmon, Mark Andrew 1993

机译：跨膜α-螺旋之间的特定相互作用：它们在整合膜蛋白寡聚中的作用
6. Integral membrane protein structure: transmembrane α-helices as autonomous folding domains [O] . Jean-Luc Popot -1

机译：整体膜蛋白结构：跨膜α-螺旋作为自主折叠域
7. Toward the complete membrane proteome : high coverage of integral membrane proteins through transmembrane peptide detection [O] . Fischer, Frank, Wolters, Dirk, Ruf6gner, Matthias, 2006

机译：迈向完整的膜蛋白质组学：通过跨膜肽检测，高覆盖完整膜蛋白

IMPROVING COVERAGE IN TRANSMEMBRANE DOMAINS OF INTEGRAL MEMBRANE PROTEINS WITH ULTRA-VIOLET PHOTODISSOCIATION

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